Introduction Light microscopy examination of blood slides is the main method of detecting
malaria infection; however, it has limited sensitivity. Low-density infections are most likely to …

In high-transmission regions, we expect parasite lineages within complex malaria infections
to be unrelated due to parasite inoculations from different mosquitoes. This project was …

During follow-up in antimalarial drug trials, treated subjects can be newly infected. PCR
correction is used to distinguish this re-infection from drug failure (recrudescence) and to …

Abstract Background Studies in Southeast Asia reported a strong relationship between
polymorphisms at the propeller domain of the Kelch 13 (K13) protein encoded by the …

Background Determination of the genetic diversity of malaria parasites can inform the
intensity of transmission and identify potential deficiencies in malaria control programmes …

Summary Background Low-density asymptomatic Plasmodium infections are prevalent in
endemic areas, but little is known about their natural history. The trajectories of these …

Drug efficacy trials monitor the continued efficacy of front-line drugs against falciparum
malaria. Overestimating efficacy results in a country retaining a failing drug as first-line …

Background The haemozoin crystal continues to be investigated extensively for its potential
as a biomarker for malaria diagnostics. In order for haemozoin to be a valuable biomarker, it …

The technical capability of different methods to diagnose Plasmodium in maternal peripheral
blood, placenta, and umbilical cord blood has not been assessed in Colombia and seldom …

The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of
uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine …