The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

The emergence of collagen I in vertebrates resulted in a dramatic increase in the stiffness of
the extracellular environment, supporting long-range force propagation and the …

Knowledge of human pancreas development underpins our interpretation and exploitation
of human pluripotent stem cell (PSC) differentiation toward a β-cell fate. However, almost no …

Background and aims Molecular evidence of cellular heterogeneity in the human exocrine
pancreas has not been yet established, due to the local concentration and cascade of …

Ureteric bud (UB) is the embryonic kidney progenitor tissue that gives rise to the collecting
duct and lower urinary tract. UB-like structures generated from human pluripotent stem cells …

The formation of a hierarchical vascular network, composed of arteries, veins, and
capillaries, is essential for embryogenesis and is required for the production of new …

Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …

Blood vessels are part of the stem cell niche in the developing cerebral cortex, but their in
vivo role in controlling the expansion and differentiation of neural stem cells (NSC s) in …

Objectives The aim of this study was to provide a comprehensive overview of the clinically
relevant anatomical and histological aspects of the development of the human pancreas …

The pancreatic islet is a highly vascularized endocrine micro-organ. The unique architecture
of rodent islets, a so-called core-mantle arrangement seen in two-dimensional images, led …