Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …

There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

Aging can cause morphological transformation in human microglia indicative of cell
senescence, termed microglial dystrophy. However, cellular senescence is characterized by …

Frontotemporal dementia is clinically and neuropathologically heterogeneous, but
neuroinflammation, atrophy and cognitive impairment occur in all of its principal syndromes …

Frontotemporal lobar degeneration with tau (FTLD-tau) is a group of tauopathies that
underlie∼ 50% of FTLD cases. Identification of genetic risk variants related to …

Microglia constitute the brain's immune system and their involvement in Alzheimer's disease
has been discussed. Commonly, and in line with the amyloid/neuroinflammation cascade …

Alzheimer's disease (AD) is the most common form of dementia worldwide, and it contributes
up to 70% of cases. AD pathology involves abnormal amyloid beta (Aβ) accumulation, and …

Contemporary microglia morphologies include ramified, activated and amoeboid, with the
morphology of microglia considered highly coupled to the cellular function. Rod microglia …

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are
neuropathologic subtypes of frontotemporal lobar degeneration with tau inclusions (FTLD …

Frontotemporal lobar degeneration (FTLD) is a group of heterogeneous neurodegenerative
disorders affecting the frontal and temporal lobes of the brain. Nuclear loss and cytoplasmic …