Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

The TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …

Targeted therapy is a new cancer treatment approach, involving drugs that particularly target
specific proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are …

Simple Summary Persistent activation of STAT3 is frequently observed in non-small cell lung
cancer and is associated with a poor prognosis. Given the multifaceted role of STAT3 …

ABSTRACT According to the World Health Organization (WHO), cancer is the second-
highest cause of mortality worldwide, killing nearly 9.6 million people annually. Despite the …

Combination immunotherapy has emerged as a promising strategy to address the
challenges associated with immune checkpoint inhibitor (ICI) therapy in breast cancer. The …

Methods The PubMed database was searched to retrieve articles published from January 1,
2001 to April 15, 2023 using the following Medical Subject Headings (MeSH) terms:“EGFR …

Targeted therapy is a new cancer treatment approach, involving drugs that particularly target
speci c proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are involved …

Background/Aim: Osimertinib is a key drug for treating epidermal growth factor receptor
(EGFR) mutation-positive non-small cell lung cancer (NSCLC). Genetic differences may be …

Objective: To investigate the effects of EGFR-TKI combined chemotherapy on immune
function, tumor markers and oxidative stress in patients with stage-IV lung adenocarcinoma …