TET2 mutation as Prototypic Clonal Hematopoiesis Lesion
L Guarnera, BK Jha - Seminars in Hematology, 2024 - Elsevier
Loss of function TET2 mutation (TET2 MT) is one of the most frequently observed lesions in
clonal haematopoiesis (CH). TET2 a member TET-dioxygenase family of enzyme that along …
clonal haematopoiesis (CH). TET2 a member TET-dioxygenase family of enzyme that along …
[HTML][HTML] Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer
Z Zhang, D Westover, Z Tang, Y Liu, J Sun… - Journal of Translational …, 2024 - Springer
Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic
response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators …
response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators …
Recent advance in optical single-molecule detection of methylation modification and methyl-modifying enzymes
Y Han, D Yang, S Jiang, S Zhao, F Ma… - TrAC Trends in Analytical …, 2024 - Elsevier
As the predominant epigenetic markers, methyl-modifying enzymes-catalyzed methylation
modification widely participates in the regulation of cellular functions, and the dysregulation …
modification widely participates in the regulation of cellular functions, and the dysregulation …
[HTML][HTML] Tissue engineering approaches for dental pulp regeneration: The development of novel bioactive materials using pharmacological epigenetic inhibitors
RM Quigley, M Kearney, OD Kennedy, HF Duncan - Bioactive Materials, 2024 - Elsevier
The drive for minimally invasive endodontic treatment strategies has shifted focus from
technically complex and destructive root canal treatments towards more conservative vital …
technically complex and destructive root canal treatments towards more conservative vital …
[HTML][HTML] Bivalent chromatin: a developmental balancing act tipped in cancer
E Glancy, N Choy… - Biochemical Society …, 2024 - portlandpress.com
Bivalent chromatin is defined by the co-occurrence of otherwise opposing H3K4me3 and
H3K27me3 modifications and is typically located at unmethylated promoters of lowly …
H3K27me3 modifications and is typically located at unmethylated promoters of lowly …
Targeting O-GlcNAcylation in cancer therapeutic resistance: The sugar Saga continues
L Chen, M Hu, L Chen, Y Peng, C Zhang, X Wang, X Li… - Cancer Letters, 2024 - Elsevier
Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation), a dynamic post-
translational modification (PTM), holds profound implications in controlling various cellular …
translational modification (PTM), holds profound implications in controlling various cellular …
Intrauterine arsenic exposure induces glucose metabolism disorders in adult offspring by targeting TET2-mediated DNA hydroxymethylation reprogramming of HNF4α …
X Peng, H Li, D Wang, L Wu, J Hu, F Ye… - Journal of Hazardous …, 2024 - Elsevier
Exposure to arsenic during gestation has lasting health-related effects on the developing
fetus, including an increase in the risk of metabolic disease later in life. Epigenetics is a …
fetus, including an increase in the risk of metabolic disease later in life. Epigenetics is a …
[HTML][HTML] High estrogen during ovarian stimulation induced loss of maternal imprinted methylation that is essential for placental development via overexpression of …
X Lu, J Mao, C Qian, H Lei, F Mu, H Sun, S Yan… - Cell Communication and …, 2024 - Springer
Background Ovarian stimulation (OS) during assisted reproductive technology (ART)
appears to be an independent factor influencing the risk of low birth weight (LBW). Previous …
appears to be an independent factor influencing the risk of low birth weight (LBW). Previous …
Dynamic deformylation of 5-formylcytosine and decarboxylation of 5-carboxylcytosine during differentiation of mouse embryonic stem cells into mouse neurons
Y Feng, YQ Tian, YQ Zhao, SJ Chen, BF Yuan - Chinese Chemical Letters, 2024 - Elsevier
Regulation of cell fate requires the establishment and erasure of 5-methylcytosine (5mC) in
genomic DNA. The formation of 5mC is achieved by DNA cytosine methyltransferases …
genomic DNA. The formation of 5mC is achieved by DNA cytosine methyltransferases …
Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus
RZ Karabaeva, TA Vochshenkova… - Frontiers in …, 2024 - frontiersin.org
Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and
environmental factors, poses a significant risk for the development of coronary artery …
environmental factors, poses a significant risk for the development of coronary artery …