Quinoline and quinolone motifs which act as structural subunits of more complex natural
products are ubiquitous in nature, and they are useful pharmacophores which play a pivotal …

Bacterial infections are account for the majority of hospital-acquired and community-
acquired infections. The emergency and widespread of drug-resistant pathogens has further …

In the modern scenario, the quinolone scaffold has emerged as a very potent motif
considering its clinical significance. Quinolones possess wide range of pharmacological …

The incidence of invasive bacterial infections has increased remarkably over the past two
decades, which was mainly attributed to the increasing emergence of drug-resistant bacteria …

Ciprofloxacin (CIP) a broad-spectrum antibiotic, is used extensively for the treatment of
diverse infections and diseases of bacteria origin, and this includes infections caused by E …

Bacterial infection is amongst the most common diseases in community and hospital
settings. Fluoroquinolones, exerting the antibacterial activity through binding to type II …

Hybridization of different pharmacophores from various bioactive substances into a single
molecule is the potential weapon to prevent the drug resistance since this strategy can …

Escherichia coli (E. coli) is the most common pathogen in both hospital and community
settings, and is capable of causing infections that can lead to serious consequences …

Quinoline derivatives are considered broad-spectrum pharmacological compounds that
exhibit a wide range of biological activities. Integration of quinoline moiety can improve its …

The emergence and worldwide spread of drug‐resistant bacteria have already posed a
serious threat to human life, creating the urgent need to develop potent and novel …