Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …

Objectives To assess cost-effectiveness of direct oral anticoagulants (DOACs) compared
with vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF) by pooling …

Coumarin was first discovered in Tonka bean and then widely in other plants. Coumarin has
an anticoagulant effect, and its derivative, warfarin, is a vitamin K analogue that inhibits the …

There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While
some of this heterogeneity of response is due to adherence and environmental causes …

In the Netherlands, routine mammography screening starts at age 50. This starting age may
have to be reconsidered because of the increasing breast cancer incidence among women …

Background Atrial fibrillation (AF) remains the most common form of cardiac arrhythmia.
Management of AF aims to reduce the risk of stroke, heart failure and premature mortality via …

What is known and objective With the high cost, the long‐term persistence of new oral
anticoagulants (NOACs) was lower than that of warfarin in Chinese patients with non …

Introduction Randomized clinical trials (RCTs) and real-world data (RWD) in patients with
atrial fibrillation have shown that—compared to vitamin K antagonists (VKAs)—non-VKA oral …

Abstract In 2012, the Dutch Health Council published a report addressing barriers for an
early and broad introduction of direct oral anticoagulants (DOACs). The report raised …

Introduction Economic evaluations are becoming increasingly important due to limitations in
economic resources, the expense of many new treatments, the need to allocate health …