The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of …
The American Diabetes Association (ADA) and the European Association for the Study of
Diabetes (EASD) convened a writing group to develop a consensus statement on the …
Diabetes (EASD) convened a writing group to develop a consensus statement on the …
[HTML][HTML] Engineering the next generation of cell-based therapeutics
Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …
intractable diseases through uniquely powerful modes of action. Despite notable recent …
[HTML][HTML] 3D printing of hydrogels: Rational design strategies and emerging biomedical applications
Abstract 3D printing alias additive manufacturing can transform 3D virtual models created by
computer-aided design (CAD) into physical 3D objects in a layer-by-layer manner …
computer-aided design (CAD) into physical 3D objects in a layer-by-layer manner …
[PDF][PDF] Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
NJ Hogrebe, M Ishahak, JR Millman - Cell Stem Cell, 2023 - cell.com
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
Dealing with the foreign‐body response to implanted biomaterials: strategies and applications of new materials
D Zhang, Q Chen, C Shi, M Chen, K Ma… - Advanced Functional …, 2021 - Wiley Online Library
Foreign‐body response caused by implanted biomaterials seriously impedes the function of
implants and is a major obstacle to the development of implantable biomaterials and …
implants and is a major obstacle to the development of implantable biomaterials and …
Non-invasive delivery strategies for biologics
AC Anselmo, Y Gokarn, S Mitragotri - Nature Reviews Drug Discovery, 2019 - nature.com
Biologics now constitute a significant element of available medical treatments. Owing to their
clinical and commercial success, biologics are a rapidly growing class and have become a …
clinical and commercial success, biologics are a rapidly growing class and have become a …
[HTML][HTML] Microparticles, microspheres, and microcapsules for advanced drug delivery
Microparticles, microspheres, and microcapsules are widely used constituents of
multiparticulate drug delivery systems, offering both therapeutic and technological …
multiparticulate drug delivery systems, offering both therapeutic and technological …
Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
Screening hydrogels for antifibrotic properties by implanting cellularly barcoded alginates in mice and a non-human primate
Screening implantable biomaterials for antifibrotic properties is constrained by the need for
in vivo testing. Here we show that the throughput of in vivo screening can be increased by …
in vivo testing. Here we show that the throughput of in vivo screening can be increased by …
Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques
The transplantation of pancreatic islet cells could restore glycaemic control in patients with
type 1 diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic …
type 1 diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic …