Pharmacokinetics, pharmacodynamics and drug–drug interactions of new anti-migraine drugs—Lasmiditan, gepants, and calcitonin-gene-related peptide (CGRP) …

D Szkutnik-Fiedler - Pharmaceutics, 2020 - mdpi.com
In the last few years, there have been significant advances in migraine management and
prevention. Lasmiditan, ubrogepant, rimegepant and monoclonal antibodies (erenumab …

Calcitonin gene-related peptide (CGRP)-targeted monoclonal antibodies and antagonists in migraine: current evidence and rationale

F Cohen, H Yuan, SD Silberstein - BioDrugs, 2022 - Springer
Calcitonin gene-related peptide (CGRP), a 37 amino-acid neuropeptide found mostly in
peptidergic sensory C-fibers, has been suggested to be implicated in the pathogenesis of …

[HTML][HTML] Lower Urinary Tract Symptoms in Depression: A Review

DJ Anderson, A Aucoin, CR Toups… - Health Psychology …, 2023 - ncbi.nlm.nih.gov
Abstract Lower Urinary Tract Symptoms (LUTS) are frequently present in the general
population as patients age with approximately a third of individuals experiencing LUTS …

Monthly migraine days, tablet utilization, and quality of life associated with Rimegepant–post hoc results from an open label safety study (BHV3000–201)

K Johnston, L Harris, L Powell, E Popoff, V Coric… - The Journal of …, 2022 - Springer
Background The objective of this study was to describe patterns in monthly migraine days
(MMD) and tablet utilization, and to estimate health-related quality of life (HRQoL) measures …

JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis

JJ Chen, YL Ren, CJ Shu, Y Zhang, MJ Chen… - Journal of Experimental …, 2020 - Springer
Background Gastric cancer (GC) is the most prevalent gastrointestinal tumor with an
unfavorable clinical prognosis. GC patients are largely threatened owing to metastasis and …

Outpatient Approach to resistant and refractory migraine in children and adolescents: a Narrative Review

A Marshall, R Lindsay, MA Clementi… - Current Neurology and …, 2022 - Springer
Abstract Purpose of Review Migraine is one of the top reasons for consulting a pediatric
neurologist. Although the majority of children and adolescents who receive evidence-based …

A systematic review with expert opinion on the role of gepants for the preventive and abortive treatment of migraine

AA Argyriou, E Mantovani, DD Mitsikostas… - Expert Review of …, 2022 - Taylor & Francis
Introduction Gepants are small molecules targeting the calcitonin gene-related peptide
(CGRP) that have been recently introduced and are under additional clinical development …

Comparative efficacy of oral calcitonin-gene–related peptide antagonists for the treatment of acute migraine: updated meta-analysis

DK Ha, MJ Kim, N Han, JH Kwak, IH Baek - Clinical drug investigation, 2021 - Springer
Abstract Background and Objective The calcitonin gene-related peptide (CGRP) is a new
therapeutic target in migraine—a common disorder resulting in reduced quality of life. The …

Evaluating rimegepant for the treatment of migraine

T de Vries, L Al-Hassany… - Expert opinion on …, 2021 - Taylor & Francis
Introduction Calcitonin gene-related peptide (CGRP) is a vasodilatory neuropeptide
involved in the pathophysiology of migraine, a highly disabling neurovascular disorder …

[HTML][HTML] Rimegepant for the treatment of migraine

AA Berger, A Winnick, AH Carroll… - Health psychology …, 2022 - ncbi.nlm.nih.gov
Migraine is a common form of primary headache, affecting up to 1 in every 6 Americans. The
pathophysiology is an intricate interplay of genetic factors and environmental influence and …