Current strategies for fertility preservation include the cryopreservation of embryos, mature
oocytes or ovarian cortical tissue for autologous transplantation. However, not all patients …

Ovarian tissue cryopreservation (OTC) and subsequent transplantation (OTT) is a fertility
preservation technique widely offered to prepubertal girls and young fertile women who …

Objective: To investigate the effects of different concentrations of N-acetylcysteine on
follicular growth and morphology, as well as on viability, levels of reactive oxygen species …

Ovarian reserve (OR) is mainly determined by the number of primordial follicles in the ovary
and continuously depleted until ovarian senescence. With the development of assisted …

There is a great deal of potential for in vitro follicle growth to provide an alternative approach
to fertility preservation. This strategy reduces the possibility of cancer cells re-exposure after …

The survival of childhood Wilms tumor is currently around 90%, with many survivors
reaching reproductive age. Chemotherapy and radiotherapy are established risk factors for …

The outcome for adolescents and young adults (AYA) with acute lymphoblastic leukemia
(ALL) has improved, mostly based on the use of pediatric-inspired intensive protocols. Due …

Considerable progress has been made with the development of culture systems for the in
vitro growth and maturation (IVGM) of oocytes from the earliest-staged primordial follicles …

Efficient germline mtDNA editing is required to construct disease-related animal models and
future gene therapy. Recently, the DddA-derived cytosine base editors (DdCBEs) have …

Objective: This paper serves as an up-to-date narrative review of the most effective methods
and outcomes of ovarian tissue cryopreservation (OTC) with new data comparing this …