Neurobehavioral and neurobiochemical effect of atomoxetine and N-acetylcysteine in streptozotocin diabetes induced endothelial dysfunction and related dementia

H Aggarwal, S Gupta, P Sharma, BM Sharma… - Physiology & …, 2022 - Elsevier
Metabolic conditions like diabetes, is a major risk factor for the development of dementia of
vascular origin. This study investigates the efficacy of atomoxetine (ATX) and N …

Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and …

B Sharma, N Singh - Pharmacology Biochemistry and Behavior, 2013 - Elsevier
Cognitive disorders are likely to increase over the coming years (5–10). Vascular dementia
(VaD) has heterogeneous pathology and is a challenge for clinicians. Current Alzheimer's …

Salutary effect of NFκB inhibitor and folacin in hyperhomocysteinemia–hyperlipidemia induced vascular dementia

B Sharma, N Singh - Progress in Neuro-Psychopharmacology and …, 2012 - Elsevier
Dementia of vascular origin or vascular dementia (VaD) is considered as the second
commonest form of dementia after Alzheimer's disease (AD). In the last ten years various …

Efficacy of bosentan, a dual ETA and ETB endothelin receptor antagonist, in experimental diabetes induced vascular endothelial dysfunction and associated dementia …

G Singh, B Sharma, AS Jaggi, N Singh - Pharmacology Biochemistry and …, 2014 - Elsevier
The study was designed to investigate the efficacy of bosentan a dual endothelin (ET A and
ET B) receptor antagonist in experimental diabetes induced vascular endothelial dysfunction …

Reversal in cognition impairments, cholinergic dysfunction, and cerebral oxidative stress through the modulation of ryanodine receptors (RyRs) and cysteinyl …

P Singh, B Sharma - Current neurovascular research, 2016 - ingentaconnect.com
Chronic cerebral hypoperfusion (CCH) is a general pathophysiological condition occurring
in vascular dementia (VaD) associated with negative impact on cognitive functions …

Modulation of transient receptor potential vanilloid subtype 1 (TRPV1) and norepinephrine transporters (NET) protect against oxidative stress, cellular injury, and …

S Gupta, B Sharma, P Singh… - Current neurovascular …, 2014 - ingentaconnect.com
Chronic cerebral hypoperfusion (CCH) is a risk factor for the development of vascular
dementia (VaD). CCH participates in a negative role in cognitive impairments. Transient …

Neuroprotective effects of nicorandil in chronic cerebral hypoperfusion-induced vascular dementia

S Gupta, P Singh, B Sharma - Journal of Stroke and Cerebrovascular …, 2016 - Elsevier
Background Ischemia-induced chronic cerebral hypoperfusion (CCH) is associated with
reduced cerebral blood flow and vascular dementia (VaD). Brain mitochondrial potassium …

Pharmacological investigations on potential of peroxisome proliferator-activated receptor-gamma agonists in hyperhomocysteinemia-induced vascular dementia in …

H Sain, B Sharma, AS Jaggi, N Singh - Neuroscience, 2011 - Elsevier
The present study has been designed to investigate the potential of peroxisome proliferator-
activated receptor-gamma ([PPAR]-γ) agonists, pioglitazone, and rosiglitazone in …

Effect of ruthenium red, a ryanodine receptor antagonist in experimental diabetes induced vascular endothelial dysfunction and associated dementia in rats

S Jain, B Sharma - Physiology & Behavior, 2016 - Elsevier
Diabetes mellitus is considered as a main risk factor for vascular dementia. In the past, we
have reported the induction of vascular dementia by experimental diabetes. This study …

[HTML][HTML] Characterization of aged male BALB/ccenp mice as a model of dementia

N Esquivel, Y García, B Lores, M Gutiérrez… - Laboratory animal …, 2020 - Springer
Dementia is defined as cognitive impairment in more than one cognitive area and leads to
an abnormal degree of impairment in the ability to remember past events. Among mice …