Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA–salt hypertension-induced vascular dementia in rats

B Sharma, N Singh - Psychopharmacology, 2012 - Springer
Rationale Vascular dementia and hypertension are increasing day by day, with a high
degree of co-occurrence. Tremendous amount of research work is required so that new …

[HTML][HTML] Bamboo leaf extract improves spatial learning ability in a rat model with senile dementia

J Liu, M Zhu, C Feng, H Ding, Y Zhan… - Journal of Zhejiang …, 2015 - ncbi.nlm.nih.gov
Senile dementia (SD) is a syndrome characterized by progressive neurological
deterioration. Treatment for the disease is still under investigation. Bamboo leaf extract (B …

Selective serotonin-norepinephrine re-uptake inhibition limits renovas-cular-hypertension induced cognitive impairment, endothelial dysfunction, and oxidative stress …

P Singh, B Sharma - Current Neurovascular Research, 2016 - ingentaconnect.com
Hypertension has been reported to induce cognitive decline and dementia of vascular
origin. Serotonin-norepinephrine reuptake transporters take part in the control of …

Thromboxane A2 synthase inhibition ameliorates endothelial dysfunction, memory deficits, oxidative stress and neuroinflammation in rat model of streptozotocin …

P Bhatia, N Singh - Physiology & Behavior, 2021 - Elsevier
Abstract Rationale Vascular dementia (VaD) is the second leading cause of dementia
worldwide. It is very important to find the possible pharmacological agents which may be …

Upregulation of NADPH-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: Development of …

MA Ansari, A Al-Jarallah, MS Rao, A Babiker… - Brain Research, 2024 - Elsevier
NADPH-oxidase (NOX) is a multi-subunit enzyme complex. The upregulation of NOX causes
massive production of superoxide (O 2 radical dot¯), which avidly reacts with nitric oxide …

Beneficial effect of lupeol and metformin in mouse model of intracerebroventricular streptozotocin induced dementia

K Ram, K Kumar, D Singh, D Chopra, V Mani… - Metabolic Brain …, 2024 - Springer
This study examines the effectiveness of lupeol and metformin in a mouse model of
dementia generated by intracerebroventricular streptozotocin (icv, STZ). Dementia was …

Caloric restriction in mice improves short-term recognition memory and modifies the neuroinflammatory response in the hippocampus of male adult offspring

TQ de Oliveira, AC de Moura, V Feistauer… - Behavioural Brain …, 2022 - Elsevier
Restrictive diets (RD) can influence the inflammatory phenotype of dams and their offspring.
Thus, this study aimed to evaluate the effects of caloric restriction on the neuroinflammatory …

[HTML][HTML] Effect of Garcinia mangostana pericarp extract on glial NF‑κB levels and expression of serum inflammation markers in an obese‑type 2 diabetes mellitus …

M Muniroh, Y Nindita, V Karlowee… - Biomedical …, 2021 - spandidos-publications.com
Type 2 diabetes mellitus (T2DM) is an age‑related disease associated with cerebral
inflammation and Alzheimer's disease. Garcinia mangostana pericarp (GMP) possesses …

Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid …

P Bhatia, G Kaur, N Singh - Vascular Pharmacology, 2021 - Elsevier
The present study investigates the potential of ozagrel, a thromboxane A2 (TXA2) synthase
inhibitor, in bilateral common carotid artery occlusion (BCCAo) induced vascular dementia …

In vivo and in vitro attenuation of naloxone-precipitated experimental opioid withdrawal syndrome by insulin and selective KATP channel modulator

P Singh, B Sharma, S Gupta, BM Sharma - Psychopharmacology, 2015 - Springer
Rationale Opiate exposure for longer duration develops state of dependence in humans and
animals, which is revealed by signs and symptoms of withdrawal precipitated by opioid …