Possible role of endothelin receptor against hyperhomocysteinemia and β-amyloid induced AD type of vascular dementia in rats

M Singh, A Prakash - Brain Research Bulletin, 2017 - Elsevier
Vascular dementia (VaD) is considered as the second commonest form of dementia after
Alzheimer's disease (AD). The study was designed to investigate the effect of endothelin …

Potential of carnosine, a histamine precursor in rat model of bilateral common carotid artery occlusion‐induced vascular dementia

N Tiwari, P Bhatia, A Kumar, AS Jaggi… - Fundamental & …, 2018 - Wiley Online Library
The present study investigates the potential of Carnosine, a histamine precursor in rat model
of bilateral common carotid artery occlusion (BCCA o)‐induced vascular dementia (VaD) …

Piracetam facilitates the anti-amnesic but not anti-diabetic activity of metformin in experimentally induced type-2 diabetic encephalopathic rats

S Pandey, D Garabadu - Cellular and Molecular Neurobiology, 2017 - Springer
Piracetam exhibits anti-amnesic activity in several animal models of dementia. However, its
anti-amnesic potential has yet to be evaluated in type-2 diabetes mellitus (T2DM)-induced …

Beneficial effect of protein tyrosine phosphatase inhibitor and phytoestrogen in dyslipidemia-induced vascular dementia in ovariectomized rats

A Verma, S Sharma - Journal of Stroke and Cerebrovascular Diseases, 2015 - Elsevier
Background Estrogen deficiency and increase in protein tyrosine phosphatase (PTPase)
activity may be a key mechanism in postmenopausal dyslipidemia–induced vascular …

Combination of HIV-1 and diabetes enhances blood brain barrier injury via effects on brain endothelium and pericytes

S Rom, S Gajghate, M Winfield… - International Journal of …, 2020 - mdpi.com
Despite combined antiretroviral therapy (ART) achieving efficient HIV replication control, HIV-
associated neurocognitive disorders (HAND) continue to be highly prevalent in HIV-infected …

Ameliorative effect of ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia‐induced experimental vascular cognitive impairment and dementia

P Bhatia, N Singh - Fundamental & Clinical Pharmacology, 2021 - Wiley Online Library
The present study investigates the effect of ozagrel, a selective thromboxane A2 (TXA2)
inhibitor, in rat model of hyperhomocysteinemia (HHcy)‐induced vascular cognitive …

Possible role of pannexin 1/P2x7 purinoceptor in neuroprotective mechanism of ischemic postconditioning in mice

N Mahi, A Kumar, AS Jaggi, N Singh… - Journal of Surgical …, 2015 - Elsevier
Background Previous studies have suggested a significant role of pannexin 1 (Panx1)/P 2 X
7 receptor complex in cardioprotective mechanism of ischemic preconditioning and …

[PDF][PDF] The anti-oxidative and cognitive properties of Zingiber officinale rhizome ethanol extract and its dichloromethane and n-hexane fractions against aluminium …

UA Inwang, KG Davies, MB Ekong… - International Journal …, 2023 - researchgate.net
Aluminium neurotoxicity is implicated in Alzheimer's disease, this multifactorial disorder, with
neurodegeneration and dementia as hallmarks. Aluminium toxicity is due to imbalances …

[引用][C] 血管性痴呆动物模型的研究现状

陈翔, 高风超, 田新英 - 医学综述, 2013

Ameliorative effect of phosphodiesterase-5 inhibitor in rat model of vascular dementia

P Bhatia, N Singh - Current Neurovascular Research, 2019 - ingentaconnect.com
Introduction: Cerebral hypoperfusion has been considered as major risk factor for Vascular
Dementia (VaD). The present study shows the potential of Tadalafil, a phosphodiesterase-5 …