Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX,
has considerably advanced our understanding of thyroid development, congenital thyroid …

Thyroid hormone has important physiologic functions in nearly every organ system. The
critical role of thyroid hormone in growth and in physical and neurologic development lends …

Untreated congenital hypothyroidism (CH) leads to intellectual disabilities. Prompt diagnosis
by newborn screening (NBS) leading to early and adequate treatment results in grossly …

To review the characteristics of newborn screening of congenital hypothyroidism (CH), we
reviewed the newborn screening data, including the levels of blood spot thyroid-stimulating …

Objective Results of the screening of disease causative mutations in congenital
hypothyroidism (CH) vary significantly, depending on the sequence strategy, patients' …

The foregut endoderm gives rise to several organs including liver, pancreas, lung and
thyroid with important roles in human physiology. Understanding which genes and …

Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder with a
genetic origin. The purpose of the present study was to analyze the mutation spectrum of CH …

To identify the spectrum and prevalence of thirteen causative genes mutations in congenital
hypothyroidism (CH) patients, we collected blood samples and extracted genomic DNA of …

Congenital hypothyroidism is one of the most common preventable endocrine disorders
associated with thyroid dysgenesis or dyshormonogenesis. Thyroid peroxidase (TPO) gene …

Ectopic thyroid tissue is a rare developmental abnormality arising from an aberration in the
normal migration of the thyroid gland, from the floor of the primitive foregut to its final …