A coordinated, multidisciplinary approach to care is essential for optimum management of
the primary manifestations and secondary complications of Duchenne muscular dystrophy …

A new paradigm has emerged for osteogenesis imperfecta as a collagen-related disorder.
The more prevalent autosomal dominant forms of osteogenesis imperfecta are caused by …

Background Osteogenesis imperfecta is caused by a genetic defect resulting in an abnormal
type I collagen bone matrix which typically results in multiple fractures with little or no …

Osteogenesis imperfecta is a genetic disorder characterized by low bone mass, decreased
bone strength, increased bone fragility, and shortened stature. Autosomal dominant …

Osteogenesis imperfecta (OI) is the most prevalent heritable bone fragility disorder in
children. It has been known for three decades that the majority of individuals with OI have …

Osteogenesis imperfecta (OI) is a monogenic bone fragility disorder that usually is caused
by mutations in one of the two genes coding for collagen type I alpha chains, COL1A1 or …

Publisher Summary Osteogenesis imperfecta (OI) or “brittle bone disease” is characterized
by reduced skeletal mass and bone fragility. OI has served as the paradigm for heritable …

This article reviews the manifestations and risk factors associated with osteoporosis in
childhood, the definition of osteoporosis and recommendations for monitoring and …

Background Children with osteogenesis imperfecta are often treated with intravenous
bisphosphonates. We aimed to assess the safety and efficacy of risedronate, an orally …

abstract Context: Information on the use of oral bisphosphonate agents to treat pediatric
osteogenesis imperfecta (OI) is limited. Objective: The objective of the investigation was to …