The discovery of ketamine as a rapid-acting antidepressant led to a new era in the
development of neuropsychiatric therapeutics, one characterized by an antidepressant …

Bipolar depression remains a clinical challenge with a quarter of patients failing to respond
to initial conventional treatments. Although ketamine has been extensively studied in …

In response to a recent call to rid psychedelic science of the concept of mystical experience,
we argue that acknowledging the varieties and weirdness of psychedelic experiences …

Purpose To systematically assess the evidence of efficacy and safety of the use of ketamine
and esketamine for patients with treatment-resistant depression (TRD) with suicidal ideation …

Ketamine is a novel drug used for treatment-resistant depression. KETAMINE RESPONSE
AND BIPOLAR DISORDER SUBTYPE This study raises an important question-does …

Background: The therapeutic potential of subanesthetic doses of ketamine appears
promising in unipolar depression; however, its effectiveness in treating bipolar depression …

Ketamine has shown rapid antidepressant and anti-suicidal effects in treatment-resistant
depression (TRD) with single and serial intravenous (IV) infusions, but the effectiveness for …

Introduction Inflammasome complexes, especially the NLRP3, have gained great attention
as a potential therapeutic target in mood disorders. NLRP3 triggers a caspase 1-dependent …

Bipolar depression constitutes a major problem in psychiatry. It correlates with high
suicidality, treatment resistance, chronicity, and poor quality of life. Registered treatment for …

In this study, a novel floating, controlled-release and core-shell oral tablet of ketamine
hydrochloride (HCl) was produced using a dual extrusion by 3D printing method. A mixture …