Dendritic spine and synapse pathology in chromatin modifier-associated autism spectrum disorders and intellectual disability
Formation of dendritic spine and synapse is an essential final step of brain wiring to
establish functional communication in the developing brain. Recent findings have displayed …
establish functional communication in the developing brain. Recent findings have displayed …
Transition from animal-based to human induced pluripotent stem cells (iPSCs)-based models of neurodevelopmental disorders: Opportunities and challenges
S Guerreiro, P Maciel - Cells, 2023 - mdpi.com
Neurodevelopmental disorders (NDDs) arise from the disruption of highly coordinated
mechanisms underlying brain development, which results in impaired sensory, motor and/or …
mechanisms underlying brain development, which results in impaired sensory, motor and/or …
Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming
Autism spectrum disorder is characterized by early postnatal symptoms, although little is
known about the mechanistic deviations that produce them and whether correcting them has …
known about the mechanistic deviations that produce them and whether correcting them has …
Developmental exposure to a human-relevant polychlorinated biphenyl mixture causes behavioral phenotypes that vary by sex and genotype in juvenile mice …
S Sethi, KP Keil Stietz, AE Valenzuela… - Frontiers in …, 2021 - frontiersin.org
Polychlorinated biphenyls (PCBs) are putative environmental risks for neurodevelopmental
disorders. Here, we tested two hypotheses:(1) developmental exposure to a human-relevant …
disorders. Here, we tested two hypotheses:(1) developmental exposure to a human-relevant …
Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models of Cdkl5 deficiency
A Adhikari, FKB Buchanan, TA Fenton… - Human molecular …, 2022 - academic.oup.com
Many neurodevelopmental disorders (NDDs) are the result of mutations on the X
chromosome. One severe NDD resulting from mutations on the X chromosome is CDKL5 …
chromosome. One severe NDD resulting from mutations on the X chromosome is CDKL5 …
[HTML][HTML] PDZD8 disruption causes cognitive impairment in humans, mice, and fruit flies
AH Al-Amri, P Armstrong, M Amici, C Ligneul… - Biological …, 2022 - Elsevier
Background The discovery of coding variants in genes that confer risk of intellectual
disability (ID) is an important step toward understanding the pathophysiology of this common …
disability (ID) is an important step toward understanding the pathophysiology of this common …
Gait as a quantitative translational outcome measure in Angelman syndrome
Angelman syndrome (AS) is a genetic neurodevelopmental disorder characterized by
developmental delay, lack of speech, seizures, intellectual disability, hypotonia, and motor …
developmental delay, lack of speech, seizures, intellectual disability, hypotonia, and motor …
Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice
Y Fu, Y Zhang, R Liu, M Xu, J Xie, X Zhang… - Journal of …, 2024 - Springer
Background The transplantation of exosomes derived from human adipose-derived
mesenchymal stem cells (hADSCs) has emerged as a prospective cellular-free therapeutic …
mesenchymal stem cells (hADSCs) has emerged as a prospective cellular-free therapeutic …
ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum
C Martins-Costa, A Wiegers, VA Pham, J Sidhaye… - Cell Stem Cell, 2024 - cell.com
Mutations in ARID1B, a member of the mSWI/SNF complex, cause severe
neurodevelopmental phenotypes with elusive mechanisms in humans. The most common …
neurodevelopmental phenotypes with elusive mechanisms in humans. The most common …
Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman syndrome
Abstract Background Angelman Syndrome (AS) is a rare neurodevelopmental disorder for
which there is currently no cure or effective therapeutic. Since the genetic cause of AS is …
which there is currently no cure or effective therapeutic. Since the genetic cause of AS is …