Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

The cysteine (Cys) proteome is a major component of the adaptive interface between the
genome and the exposome. The thiol moiety of Cys undergoes a range of biologic …

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal
inflammatory response, RIPK1 is regulated post-translationally by well-characterized …

Apoptosis—the regulated destruction of a cell—is a complicated process. The decision to
die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of …

Apoptosis is orchestrated by a family of cysteine proteases known as the caspases.
Fourteen mammalian caspases have been identified, three of which (caspase-3,-6, and-7) …

Caspases are a family of cysteine proteases that play important roles in regulating
apoptosis. A decade of research has generated a wealth of information on the signal …

Apoptosis is an evolutionarily conserved and tightly regulated cell death pathway.
Physiological cell death is important for maintaining homeostasis and optimal biological …

The death morphology commonly known as apoptosis results from a post-translational
pathway driven largely by specific limited proteolysis. In the last decade the structural basis …

It is increasingly recognized that many key biological processes, including apoptosis, are
carried out within very large multi-protein complexes. Apoptosis can be initiated by activation …

The Apaf‐1 apoptosome is a multi‐subunit caspase‐activating scaffold that is assembled in
response to diverse forms of cellular stress that culminate in apoptosis. To date, most studies …