Secretory IgA (SIgA) is the dominant antibody class in mucosal secretions. The majority of
plasma cells producing IgA are located within mucosal membranes lining the intestines …

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide. It is a leading cause of chronic kidney disease and progresses to end-stage …

Data are accumulating that emphasize the important role of the intestinal barrier and
intestinal permeability for health and disease. However, these terms are poorly defined, their …

Prevention of infections by vaccination remains a compelling goal to improve public health.
Mucosal vaccines would make immunization procedures easier, be better suited for mass …

Abstract Introduction Immunoglobulin A (IgA) deficiency is the most common primary
immunodeficiency defined as decreased serum level of IgA in the presence of normal levels …

In mammals, the gastrointestinal tract harbors an extraordinarily dense and complex
community of microorganisms. The gut microbiota provide strong selective pressure to the …

It has long been recognized that the mammalian gut microbiota has a role in the
development and activation of the host immune system. Much less is known on how host …

Abundant evidence supports the notion that human intestinal plasma cells are largely
derived from B cells initially activated in gut-associated lymphoid tissue (GALT) …

Eosinophils are multifunctional leukocytes that reside in the gastrointestinal (GI) lamina
propria, where their basal function remains largely unexplored. In this study, by examining …

In the Peyer's patches (PPs), germinal centers (GCs) are chronically induced by bacteria
and are the major sites for generation of gut immunoglobulin A (IgA) immune responses …