The CB 1 and CB 2 cannabinoid receptors (CB 1 R, CB 2 R) are members of the G protein-
coupled receptor (GPCR) family that were identified over 20 years ago. CB 1 Rs and CB 2 …

Cannabis has been used for centuries to treat seizures. Recent anecdotal reports,
accumulating animal model data, and mechanistic insights have raised interest in cannabis …

Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies
show reversible downregulation of brain cannabinoid CB 1 (cannabinoid receptor type 1) …

There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-
proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 …

Cannabinoids have a long history of consumption for recreational and medical reasons. The
primary active constituent of the hemp plant Cannabis sativa is Δ9-tetrahydrocannabinol (Δ9 …

Background The widespread use of cannabis, the increasing legalization of “medical”
cannabis, the increasing potency of cannabis, and the growing recreational use of synthetic …

Cannabis is one of the most widely used drugs throughout the world. The psychoactive
constituent of cannabis, δ9‐tetrahydrocannabinol (δ9‐THC), produces a myriad of …

In the last 25 years data has grown exponentially dealing with the discovery of the
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …

Δ9-Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs
such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528 …

The cannabinoid receptor family currently includes twotypes: CB 1, characterized in
neuronal cells and brain, and CB 2, characterized in immune cells and tissues. CB 1 and CB …