Application of lipid nanoparticles to ocular drug delivery
L Battaglia, L Serpe, F Foglietta, E Muntoni… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Although eye drops are widely used as drug delivery systems for the anterior
segment of the eye, they are also associated with poor drug bioavailability due to transient …
segment of the eye, they are also associated with poor drug bioavailability due to transient …
Current drug treatments targeting dopamine D3 receptor
Dopamine receptors (DR) have been extensively studied, but only in recent years they
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …
[HTML][HTML] Optical coherence tomography angiography of the superficial microvasculature in the macular and peripapillary areas in glaucomatous and healthy eyes
HSL Chen, CH Liu, WC Wu, HJ Tseng… - … & visual science, 2017 - tvst.arvojournals.org
Purpose: To quantitatively evaluate the superficial microvasculature in the macular and
peripapillary areas in glaucomatous and healthy eyes using optical coherence tomography …
peripapillary areas in glaucomatous and healthy eyes using optical coherence tomography …
[HTML][HTML] Discovery and preclinical development of netarsudil, a novel ocular hypotensive agent for the treatment of glaucoma
A MooreLori, L LaethemCarmen… - Journal of Ocular …, 2018 - liebertpub.com
Purpose: Rho-associated protein kinase (ROCK) inhibitors lower intraocular pressure (IOP)
by increasing aqueous outflow through the trabecular meshwork (TM). The preclinical …
by increasing aqueous outflow through the trabecular meshwork (TM). The preclinical …
Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis
Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening
adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the …
adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the …
FP and EP2 prostanoid receptor agonist drugs and aqueous humor outflow devices for treating ocular hypertension and glaucoma
NA Sharif, N Odani-Kawabata, F Lu… - Experimental Eye …, 2023 - Elsevier
Prostaglandin (PG) receptors represent important druggable targets due to the many diverse
actions of PGs in the body. From an ocular perspective, the discovery, development, and …
actions of PGs in the body. From an ocular perspective, the discovery, development, and …
Pharmacologic characterization of omidenepag isopropyl, a novel selective EP2 receptor agonist, as an ocular hypotensive agent
T Kirihara, T Taniguchi, K Yamamura… - … & Visual Science, 2018 - iovs.arvojournals.org
Purpose: The objective of this study was to investigate the pharmacologic characteristics of
omidenepag isopropyl (OMDI), a compound developed as a novel intraocular pressure …
omidenepag isopropyl (OMDI), a compound developed as a novel intraocular pressure …
Thermosensitive hexanoyl glycol chitosan-based ocular delivery system for glaucoma therapy
Conventional eye drops quickly move away from the surface of the eye; as a result, ocular
bioavailability is very limited. To overcome this issue, we developed a thermosensitive …
bioavailability is very limited. To overcome this issue, we developed a thermosensitive …
Development of a Δ9-tetrahydrocannabinol amino acid-dicarboxylate prodrug with improved ocular bioavailability
Purpose: The aim of the present study was to evaluate the utility of the relatively hydrophilic
Δ 9-tetrahydrocannabinol (THC) prodrugs, mono and di-valine esters (THC-Val and THC …
Δ 9-tetrahydrocannabinol (THC) prodrugs, mono and di-valine esters (THC-Val and THC …
Novel therapeutics in glaucoma management
Background: Glaucoma is a progressive optic neuropathy characterized by retinal ganglion
cell death and alterations of visual field. Elevated intraocular pressure (IOP) is considered …
cell death and alterations of visual field. Elevated intraocular pressure (IOP) is considered …