Introduction: Although eye drops are widely used as drug delivery systems for the anterior
segment of the eye, they are also associated with poor drug bioavailability due to transient …

Dopamine receptors (DR) have been extensively studied, but only in recent years they
became object of investigation to elucidate the specific role of different subtypes (D1R, D2R …

Purpose: To quantitatively evaluate the superficial microvasculature in the macular and
peripapillary areas in glaucomatous and healthy eyes using optical coherence tomography …

Purpose: Rho-associated protein kinase (ROCK) inhibitors lower intraocular pressure (IOP)
by increasing aqueous outflow through the trabecular meshwork (TM). The preclinical …

Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening
adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the …

Prostaglandin (PG) receptors represent important druggable targets due to the many diverse
actions of PGs in the body. From an ocular perspective, the discovery, development, and …

Purpose: The objective of this study was to investigate the pharmacologic characteristics of
omidenepag isopropyl (OMDI), a compound developed as a novel intraocular pressure …

Conventional eye drops quickly move away from the surface of the eye; as a result, ocular
bioavailability is very limited. To overcome this issue, we developed a thermosensitive …

Purpose: The aim of the present study was to evaluate the utility of the relatively hydrophilic
Δ 9-tetrahydrocannabinol (THC) prodrugs, mono and di-valine esters (THC-Val and THC …

Background: Glaucoma is a progressive optic neuropathy characterized by retinal ganglion
cell death and alterations of visual field. Elevated intraocular pressure (IOP) is considered …