Considering the complexity of the current framework in oncology, the relevance of animal
models in biomedical research is critical in light of the capacity to produce valuable data with …

Advances in high-throughput sequencing over the past decades have led to the
identification of thousands of non-coding RNAs (ncRNAs), which play a major role in …

Circadian rhythm disruption (CRD) is a shared characteristic of various brain disorders, such
as Alzheimer's disease (AD), Parkinson's disease (PD), and major depression disorder …

Chronic diseases are considered a major public health concern worldwide, and most of
these diseases like cancer, cardiovascular, metabolic, and neurological disorders occur due …

Calcium is a ubiquitous second messenger that is indispensable in regulating
neurotransmission and memory formation. A precise intracellular calcium level is achieved …

Sleep disturbances not only deteriorate Alzheimer's disease (AD) progress by affecting
cognitive states but also accelerate the neuropathological changes of AD. Astrocytes and …

Maintaining an active lifestyle is considered a hallmark of successful aging. Physical activity
significantly reduces the risk of cognitive decline and Alzheimer's disease in humans …

Background: Circadian rhythm is associated with the aging process and sex differences;
however, how age and sex can change circadian regulation systems remains unclear. Thus …

Background Major depression (MD) is the most prevalent psychiatric disease in the
population and is considered a prodromal stage of the Alzheimer's disease (AD). Despite …

Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor
central to the transcription/translation feedback loop of the biologic clock. Although Bmal1 is …