A critical perspective on 3D liver models for drug metabolism and toxicology studies
AS Serras, JS Rodrigues, M Cipriano… - Frontiers in cell and …, 2021 - frontiersin.org
The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
Pharmacogenomics in Asians: differences and similarities with other human populations
M Biswas, P Jinda, C Sukasem - Expert Opinion on Drug …, 2023 - Taylor & Francis
ABSTRACT Introduction Various pharmacogenomic (PGx) variants differ widely in different
ethnicities. and clinical outcomes associated with these variants may also be substantially …
ethnicities. and clinical outcomes associated with these variants may also be substantially …
LaGAT: link-aware graph attention network for drug–drug interaction prediction
Motivation Drug–drug interaction (DDI) prediction is a challenging problem in pharmacology
and clinical applications. With the increasing availability of large biomedical databases …
and clinical applications. With the increasing availability of large biomedical databases …
Pharmacogenomics of impaired tyrosine kinase inhibitor response: lessons learned from chronic myelogenous leukemia
M Kaehler, I Cascorbi - Frontiers in Pharmacology, 2021 - frontiersin.org
The use of small molecules became one key cornerstone of targeted anti-cancer therapy.
Among them, tyrosine kinase inhibitors (TKIs) are especially important, as they were the first …
Among them, tyrosine kinase inhibitors (TKIs) are especially important, as they were the first …
Pharmacogenomics in psychiatry practice: the value and the challenges
A Alchakee, M Ahmed, L Eldohaji, H Alhaj… - International Journal of …, 2022 - mdpi.com
The activity of cytochrome P450 enzymes is influenced by genetic and nongenetic factors;
hence, the metabolism of exogenous psychotropic medications and potentially some …
hence, the metabolism of exogenous psychotropic medications and potentially some …
[HTML][HTML] Reviewing pharmacogenetics to advance precision medicine for opioids
L Magarbeh, I Gorbovskaya, B Le Foll, R Jhirad… - Biomedicine & …, 2021 - Elsevier
Background Adequate opioid prescribing is critical for therapeutic success of pain
management. Despite the widespread use of opioids, optimized opioid therapy remains …
management. Despite the widespread use of opioids, optimized opioid therapy remains …
Pharmacogenetics of carbamazepine and valproate: focus on polymorphisms of drug metabolizing enzymes and transporters
T Iannaccone, C Sellitto, V Manzo, F Colucci… - Pharmaceuticals, 2021 - mdpi.com
Pharmacogenomics can identify polymorphisms in genes involved in drug pharmacokinetics
and pharmacodynamics determining differences in efficacy and safety and causing inter …
and pharmacodynamics determining differences in efficacy and safety and causing inter …
[HTML][HTML] Interplay of vitamin D and CYP3A4 polymorphisms in endocrine disorders and cancer
SS Kasarla, V Garikapati, Y Kumar… - Endocrinology and …, 2022 - synapse.koreamed.org
Vitamin D has received considerable optimistic attention as a potentially important factor in
many pathological states over the past few decades. However, the proportion of the active …
many pathological states over the past few decades. However, the proportion of the active …
Drug–drug interactions in vestibular diseases, clinical problems, and medico-legal implications
G Di Mizio, G Marcianò, C Palleria, L Muraca… - International Journal of …, 2021 - mdpi.com
Peripheral vestibular disease can be treated with several approaches (eg, maneuvers,
surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is …
surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is …
Influence of CYP2D6 and CYP3A5 Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Bisoprolol in Hypertensive Chinese Patients
Purpose: This study was performed to investigate the effects of common polymorphisms in
CYP2D6 and CYP3A5 on the plasma concentrations and antihypertensive effects of …
CYP2D6 and CYP3A5 on the plasma concentrations and antihypertensive effects of …