[HTML][HTML] Novel pyridine and pyrimidine derivatives as promising anticancer agents: A review
M Albratty, HA Alhazmi - Arabian Journal of Chemistry, 2022 - Elsevier
Pyridines and pyrimidines are the class of heterocyclic nitrogenous compounds having
plethora of applications in anticancer drug development. These synthetic sources serve as …
plethora of applications in anticancer drug development. These synthetic sources serve as …
[HTML][HTML] Pyrimidine: a review on anticancer activity with key emphasis on SAR
A Mahapatra, T Prasad, T Sharma - Future journal of pharmaceutical …, 2021 - Springer
Background Cancer is a global health challenge, it impacts the quality of life and its
treatment is associated with several side effects. Resistance of the cancer cells to the …
treatment is associated with several side effects. Resistance of the cancer cells to the …
Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro …
Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M
A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
Discovery of thieno [2, 3-d] pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents
SA El-Metwally, MM Abou-El-Regal, IH Eissa… - Bioorganic …, 2021 - Elsevier
Vascular endothelial growth factor-2 (VEGFR-2) is considered one of the most important
factors in tumor angiogenesis, and consequently a number of anticancer therapeutics have …
factors in tumor angiogenesis, and consequently a number of anticancer therapeutics have …
[HTML][HTML] Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4, 5-dihydropyrazoles as anticancer agents …
Currently, the humanity is in a fierce battle against various health-related challenges
especially those associated with human malignancies. This created the urge to develop …
especially those associated with human malignancies. This created the urge to develop …
[HTML][HTML] Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro …
C Ma, MS Taghour, A Belal, ABM Mehany… - Frontiers in …, 2021 - frontiersin.org
Guided by the structural optimization principle and the promising anticancer effect of the
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis
Abstract New series of [1, 2, 4] triazolo [4, 3-a] quinoxalin-4 (5H)-one and [1, 2, 4] triazolo [4,
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …
Pyrimidine-based EGFR TK inhibitors in targeted cancer therapy
Despite significant improvements of new treatment options, cancer continues to represent as
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …
[HTML][HTML] Comprehensive virtual screening of the antiviral potentialities of marine polycyclic guanidine alkaloids against SARS-CoV-2 (COVID-19)
The huge global expansion of the COVID-19 pandemic caused by the novel SARS-corona
virus-2 is an extraordinary public health emergency. The unavailability of specific treatment …
virus-2 is an extraordinary public health emergency. The unavailability of specific treatment …