[HTML][HTML] Acetyl-CoA metabolism as a therapeutic target for cancer
G Chen, B Bao, Y Cheng, M Tian, J Song… - Biomedicine & …, 2023 - Elsevier
Acetyl-coenzyme A (acetyl-CoA), an essential metabolite, not only takes part in numerous
intracellular metabolic processes, powers the tricarboxylic acid cycle, serves as a key hub …
intracellular metabolic processes, powers the tricarboxylic acid cycle, serves as a key hub …
Poly-pharmacology of existing drugs: How to crack the code?
B Mouysset, M Le Grand, L Camoin, E Pasquier - Cancer Letters, 2024 - Elsevier
Drug development in oncology is highly challenging, with less than 5% success rate in
clinical trials. This alarming figure points out the need to study in more details the multiple …
clinical trials. This alarming figure points out the need to study in more details the multiple …
[HTML][HTML] Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome
K El Hindi, S Brachtendorf, JC Hartel, C Renné… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Sphingolipids are important for the physicochemical properties of cellular membranes and
deregulated in tumors. In human colon cancer tissue ceramide synthase (CerS) 4 and …
deregulated in tumors. In human colon cancer tissue ceramide synthase (CerS) 4 and …
[HTML][HTML] The Different Mechanisms of Lipid Accumulation in Hepatocytes Induced by Oleic Acid/Palmitic Acid and High-Fat Diet
M Zhang, X Bai, Q Du, J Xu, D Wang, L Chen, K Dong… - Molecules, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the primary chronic liver disease worldwide,
mainly manifested by hepatic steatosis. Hepatic lipids may be derived from dietary intake …
mainly manifested by hepatic steatosis. Hepatic lipids may be derived from dietary intake …
[HTML][HTML] The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7
W Chen, X Wu, J Hu, X Liu, Z Guo, J Wu… - Cardiovascular …, 2024 - Springer
Atherosclerosis is one of the leading causes of death worldwide. miR-26 is a potential
biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have …
biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have …
[HTML][HTML] Prognostic prediction and immunotherapy response analysis of the fatty acid metabolism-related genes in clear cell renal cell carcinoma
Q Yao, X Zhang, C Wei, H Chen, Q Xu, J Chen, D Chen - Heliyon, 2023 - cell.com
Background Clear cell renal cell carcinoma (ccRCC) is a common urinary cancer. Although
diagnostic and therapeutic approaches for ccRCC have been improved, the survival …
diagnostic and therapeutic approaches for ccRCC have been improved, the survival …
[HTML][HTML] Nortriptyline hydrochloride, a potential candidate for drug repurposing, inhibits gastric cancer by inducing oxidative stress by triggering the Keap1-Nrf2 …
C Zhu, Y Lu, S Wang, J Song, Y Ding, Y Wang… - Scientific Reports, 2024 - nature.com
Effective drugs for the treatment of gastric cancer (GC) are still lacking. Nortriptyline
Hydrochloride (NTP), a commonly used antidepressant medication, has been demonstrated …
Hydrochloride (NTP), a commonly used antidepressant medication, has been demonstrated …
Macropinocytosis inhibits alkaliptosis in pancreatic cancer cells through fatty acid uptake
F Chen, H Tang, J Lin, L Xiang, Y Lu, R Kang… - …, 2024 - academic.oup.com
Alkaliptosis, a form of regulated cell death, is characterized by lysosomal dysfunction and
intracellular pH alkalinization. The pharmacological induction of alkaliptosis using the small …
intracellular pH alkalinization. The pharmacological induction of alkaliptosis using the small …
Inhibition of EGFR-MAPK signaling reduces ACE2-dependent SARS-CoV-2 infection.
M Engler - 2024 - oparu.uni-ulm.de
SARS-CoV-2 is the responsible virus for the most severe pandemic of the last decades,
known as Covid-19. For viral infection, SARS-CoV-2 predominantly uses the angiotensin …
known as Covid-19. For viral infection, SARS-CoV-2 predominantly uses the angiotensin …
[PDF][PDF] BBA-Molecular Basis of Disease
K El Hindi, S Brachtendorf, JC Hartel, C Renné, K Birod… - researchgate.net
Sphingolipids are important for the physicochemical properties of cellular membranes and
deregulated in tumors. In human colon cancer tissue ceramide synthase (CerS) 4 and …
deregulated in tumors. In human colon cancer tissue ceramide synthase (CerS) 4 and …