Importance Acute respiratory distress syndrome (ARDS) is a life-threatening form of
respiratory failure that affects approximately 200 000 patients each year in the United States …

Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury
to the lung is mediated by excessive mechanical stress and strain, whereas the diaphragm …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Abstract Coronavirus Disease 2019 (COVID-19) threatens to overwhelm our medical
infrastructure at the regional level causing spikes in mortality rates because of shortages of …

Abstract Since Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was
identified in late 2019, the coronavirus disease 2019 (COVID-19) pandemic has challenged …

Very high mortality rates of coronavirus pandemic (COVID‐19) are observed around the
world due to lack of medical equipment. The increased need for medical devices and …

Mechanical ventilation with hyperoxia is the major supportive measure to treat patients with
acute lung injury and acute respiratory distress syndrome (ARDS). However, prolonged …

Objectives: Given perceived similarities between coronavirus disease 2019 pneumonia and
the acute respiratory distress syndrome, we explored whether awake self-proning improved …

This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy
mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 …

Abstract Treatment of respiratory failure has improved dramatically since the polio epidemic
in the 1950s with the use of invasive techniques for respiratory support: mechanical …