Background Diabetes mellitus is a chronic metabolic disorder associated with persistent
increased level of glucose in the blood. According to a report by World Health Organisation …

Diabetic nephropathy is one of the most common and severe complications of diabetes
mellitus, affecting one in every five patients suffering from diabetes. Despite extensive …

Key points Increased activation of the renin‐angiotensin‐aldosterone system (RAAS) and
elevated growth factor production are of crucial importance in the development of renal …

Context: Collagen accumulation around adipocytes and vessels (ie, pericellular fibrosis) is a
hallmark of obese adipose tissue associated with altered metabolism. Objective: Our …

The human body has a mechanism for balancing the generation and neutralization of
reactive oxygen species. The body is exposed to many agents that are responsible for the …

Obesity-induced inflammation presumably accelerates the development of chronic kidney
diseases. However, little is known about the sequence of these inflammatory events and …

Literature suggests that TGF-β1 has a central role in the progression of diabetic nephropathy
and its down regulation can improve the disease condition. Oxidative stress, generation of …

TGF-β plays a central role in the pathogenesis of fibroproliferative disorders. Defining the
exact underlying molecular basis is therefore critical for the development of viable …

Aims Diabetic nephropathy (DN) is a diabetes-related chronic vasculitis. DN diminishes
kidney function over time and, of course, leads to end stage renal disease in people (ESRD) …

Increased activity of transforming growth factor–β (TGF-β), which binds to and stimulates cell
surface receptors, contributes to cancer progression and fibrosis by driving epithelial cells …