Previously, we reported that α1, 6-fucosyltransferase (Fut8)-deficient (Fut8−/−) mice exhibit
emphysema-like changes in the lung and severe growth retardation due to dysregulation of …

Schizophrenia and schizotypal personality disorder share common clinical profiles,
neurobiological and genetic substrates along with Prepulse Inhibition and cognitive deficits; …

Postsynaptic density is reduced in schizophrenia, and risk variants increasing complement
component 4A (C4A) gene expression are linked to excessive synapse elimination. In two …

Evidence now suggests that compromised prenatal brain development may increase the risk
for the manifestation of neurological disorders such as schizophrenia. We present a guinea …

Animal models have long been used to explore hypotheses regarding the neurobiological
substrates of and treatments for psychiatric disorders. Early attempts to develop models that …

Commonalities in the clinical phenomenology and psychopharmacology of ADHD and
schizophrenia are reviewed. The potential of psychostimulants to produce psychotic …

Glycogen synthase kinase (GSK-3) is a key enzyme in multiple cell processes. Since many
pharmacological compounds that have effects on common metabolic pathways may have …

Glycogen synthase kinase 3beta (GSK-3β) is an enzyme with a variety of cellular functions
in addition to the regulation of glycogen metabolism. In the central nervous system, different …

Prepulse inhibition (PPI) is considered to be one of the most promising neurophysiological
indexes for translational research in psychiatry. Impairment of PPI has been reported in …

This study investigated the relationship between extraversion and rates of acoustic startle
habituation, a potential biological marker for individual differences. Personality was …