Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes
Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
Bioactive Flavonoids: A comparative overview of the biogenetic and chemical synthesis approach
Flavonoids are natural polyphenolic compounds and constitute a major class of plant
secondary metabolites. To date, structures of more than 10,000 different flavonoids have …
secondary metabolites. To date, structures of more than 10,000 different flavonoids have …
Assessment of hypolipidemic and anti‐inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton …
Atherosclerosis and cognitive impairment are both influenced by hyperlipidemia. Due to
their high margin of safety and low cost, natural chemicals have recently attracted particular …
their high margin of safety and low cost, natural chemicals have recently attracted particular …
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and …
The synthesis, characterization and biological evaluation of a series of novel N-substituted
phthalazine sulfonamide (5a-l) are disclosed. Phthalazines which are nitrogen-containing …
phthalazine sulfonamide (5a-l) are disclosed. Phthalazines which are nitrogen-containing …
Potential implications of hyperoside on oxidative stress-induced human diseases: A comprehensive review
K Wang, H Zhang, L Yuan, X Li… - Journal of inflammation …, 2023 - Taylor & Francis
Hyperoside is a flavonol glycoside mainly found in plants of the genera Hypericum and
Crataegus, and also detected in many plant species such as Abelmoschus manihot, Ribes …
Crataegus, and also detected in many plant species such as Abelmoschus manihot, Ribes …
Transition‐metal complexes of bidentate Schiff‐base ligands: in vitro and in silico evaluation as non‐classical carbonic anhydrase and potential acetylcholinesterase …
Schiff bases display superior features for many areas, such as significant intermediates in
industrial biological, pharmacological, catalytic and optical properties, organic synthesis …
industrial biological, pharmacological, catalytic and optical properties, organic synthesis …
Naphthoquinones, benzoquinones, and anthraquinones: Molecular docking, ADME and inhibition studies on human serum paraoxonase‐1 associated with …
Y Demir - Drug development research, 2020 - Wiley Online Library
Abstract Paraoxonase‐1 (PON1) has essential roles such as protecting low‐density
lipoprotein against detoxification and oxidation of highly toxic compounds. Quinones are a …
lipoprotein against detoxification and oxidation of highly toxic compounds. Quinones are a …
Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α‐glycosidase and molecular docking studies
Aldose reductase (AR) is the first and rate‐limiting enzyme of the polyol pathway, which
converts glucose to sorbitol in an NADPH‐dependent reaction. α‐Glycosidase breaks down …
converts glucose to sorbitol in an NADPH‐dependent reaction. α‐Glycosidase breaks down …
Antidiabetic properties of dietary phenolic compounds: Inhibition effects on α‐amylase, aldose reductase, and α‐glycosidase
Abstract Aldose reductase (AR), α‐amylase, and α‐glycosidase are vital enzymes to prevent
diabetic complications. Here, AR was purified from sheep kidney using elementary methods …
diabetic complications. Here, AR was purified from sheep kidney using elementary methods …