[HTML][HTML] Nutrient regulation of signaling and transcription
GW Hart - Journal of Biological Chemistry, 2019 - ASBMB
In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …
surfaces of living cells in the murine immune system, we discovered a novel form of …
Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
[HTML][HTML] O-GlcNAcylation and O-GlcNAc cycling regulate gene transcription: emerging roles in cancer
MP Parker, KR Peterson, C Slawson - Cancers, 2021 - mdpi.com
Simple Summary O-linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational
modification (PTM) linking nutrient flux through the hexosamine biosynthetic pathway (HBP) …
modification (PTM) linking nutrient flux through the hexosamine biosynthetic pathway (HBP) …
Self-assembly of promoter DNA and RNA Pol II machinery into transcriptionally active biomolecular condensates
Transcription in the nucleus occurs in a concentrated, dense environment, and no
reasonable biochemical facsimile of this milieu exists. Such a biochemical environment …
reasonable biochemical facsimile of this milieu exists. Such a biochemical environment …
Targeting O-GlcNAcylation to develop novel therapeutics
Y Zhu, GW Hart - Molecular aspects of medicine, 2021 - Elsevier
O-linked β-DN-acetylglucosamine (O-GlcNAc) is an abundant post-translational modification
(PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus …
(PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus …
Potent de novo macrocyclic peptides that inhibit O‐GlcNAc transferase through an allosteric mechanism
Glycosyltransferases are a superfamily of enzymes that are notoriously difficult to inhibit.
Here we apply an mRNA display technology integrated with genetic code reprogramming …
Here we apply an mRNA display technology integrated with genetic code reprogramming …
[HTML][HTML] Concerted transformation of a hyper-paused transcription complex and its reinforcing protein
RfaH, a paralog of the universally conserved NusG, binds to RNA polymerases (RNAP) and
ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical …
ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical …
[HTML][HTML] High OGT activity is essential for MYC-driven proliferation of prostate cancer cells
HM Itkonen, A Urbanucci, SES Martin, A Khan… - Theranostics, 2019 - ncbi.nlm.nih.gov
O-GlcNAc transferase (OGT) is overexpressed in aggressive prostate cancer. OGT modifies
intra-cellular proteins via single sugar conjugation (O-GlcNAcylation) to alter their activity …
intra-cellular proteins via single sugar conjugation (O-GlcNAcylation) to alter their activity …
Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability
VM Pravata, V Muha, M Gundogdu… - Proceedings of the …, 2019 - National Acad Sciences
O-GlcNAc transferase (OGT) is an X-linked gene product that is essential for normal
development of the vertebrate embryo. It catalyses the O-GlcNAc posttranslational …
development of the vertebrate embryo. It catalyses the O-GlcNAc posttranslational …
Inhibition of O-GlcNAc transferase renders prostate cancer cells dependent on CDK9
HM Itkonen, N Poulose, RE Steele, SES Martin… - Molecular Cancer …, 2020 - AACR
O-GlcNAc transferase (OGT) is a nutrient-sensitive glycosyltransferase that is overexpressed
in prostate cancer, the most common cancer in males. We recently developed a specific and …
in prostate cancer, the most common cancer in males. We recently developed a specific and …