Device-associated clot formation and poor tissue integration are ongoing problems with
permanent and temporary implantable medical devices. These complications lead to …

Introduction: Heart valve disease is an increasingly prevalent and clinically serious
condition. There are no clinically effective biological diagnostics or treatment strategies. The …

Infective endocarditis (IE) of prosthetic or bioprosthetic heart valves is a serious complication
associated with significant morbidity and mortality. Data on the incidence, risk factors, and …

This paper addresses a significant paradox in biomaterials science; biocompatibility
phenomena have been experienced and described for over 50 years but without an agreed …

Abstract OBJECTIVES Tirone E. David described aortic valve-sparing root reimplantion
(AVSRR) almost 30 years ago. At our centre, we adopted this operation in 1993, and since …

Polymeric heart valves seem to be an attractive alternative to mechanical and biological
prostheses as they are more durable, due to the superior properties of novel polymers, and …

Tissue-engineered heart valves (TEHVs) are emerging alternatives to current valve
prostheses and prospectively a lifelong replacement. Calcification, a pathological …

Objectives We present our 25-year experience with valve-sparing aortic root replacement
using a straight tube graft (David-I). Methods From 1993 to 2019, 677 patients (median age …

The prevalence of heart valve diseases and their significant impact on global mortality
underscore the urgency of refining heart valve technology. Despite the crucial roles of both …

Objectives Valve-conserving operations for aneurysms of the ascending aorta and root offer
many advantages, and their use is steadily increasing. Optimizing the results of these …