Sclerosing conditions of the skin are manifested by a full spectrum of presentations that
includes skin-limited forms as well as those which can involve internal organs and result in …

Morphea is a rare autoimmune condition causing inflammation and sclerosis of the skin and
underlying soft tissue. It is characterized by periods of activity (inflammation admixed with …

The term 'sclerosing diseases of the skin'comprises specific dermatological entities, which
have fibrotic changes of the skin in common. These diseases mostly manifest in different …

Background: For treatment of localized scleroderma numerous treatments, including ones
with potentially hazardous side effects, are currently used with only limited success …

We established diagnostic criteria and severity classification of localized scleroderma
because there is no established diagnostic criteria or widely accepted severity classification …

Background: Low-dose methotrexate (MTX) has been shown to be effective in the treatment
of systemic sclerosis. Objective: We evaluated the effect of low-dose MTX on widespread …

Localized scleroderma (also called morphea) is a term encompassing a spectrum of
sclerotic autoimmune diseases that primarily affect the skin, but also might involve …

Background Broad-band UVA, long-wave UVA1 and PUVA treatment have been described
as an alternative/adjunct therapeutic option in a number of inflammatory and malignant skin …

The scleroderma spectrum of disorders comprises a wide variety of disparate clinical
conditions whose unifying feature is the presence of hard skin (Table 1). In the pediatric age …

Photopheresis or extracorporeal photochemotherapy (ECP) is a novel immunomodulatory
therapy which involves separation of the patient's leucocyte‐rich plasma, followed by ex vivo …