An update on Cryptosporidium biology and therapeutic avenues

AK Dhal, C Panda, SIL Yun, RK Mahapatra - Journal of Parasitic Diseases, 2022 - Springer
Cryptosporidium species has been identified as an important pediatric diarrheal pathogen in
resource-limited countries, particularly in very young children (0–24 months). However, the …

Use-case scenarios for an anti-Cryptosporidium therapeutic

PG Ashigbie, S Shepherd, KL Steiner… - PLOS Neglected …, 2021 - journals.plos.org
Cryptosporidium is a widely distributed enteric parasite that has an increasingly appreciated
pathogenic role, particularly in pediatric diarrhea. While cryptosporidiosis has likely affected …

Metagenomic analysis of gut microbiome and resistome of diarrheal fecal samples from Kolkata, India, reveals the core and variable microbiota including signatures of …

R De, AK Mukhopadhyay, S Dutta - Gut Pathogens, 2020 - Springer
Background Metagenomic analysis of the gut microbiome and resistome is instrumental for
understanding the dynamics of diarrheal pathogenesis and antimicrobial resistance …

Associations between ambient temperature and enteric infections by pathogen: a systematic review and meta-analysis

PLC Chua, CFS Ng, A Tobias, XT Seposo… - The Lancet Planetary …, 2022 - thelancet.com
Background Numerous studies have quantified the associations between ambient
temperature and enteric infections, particularly all-cause enteric infections. However, the …

Burden of Shigella in South Asia: a systematic review and meta-analysis

BA Muzembo, K Kitahara, D Mitra… - Journal of Travel …, 2023 - academic.oup.com
Background Shigella remains one of the most common causes of diarrhoea in South Asia.
Current estimates of the prevalence of Shigella are critical for guiding control measures. We …

Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell

MC Pawlowic, M Somepalli… - Proceedings of the …, 2019 - National Acad Sciences
The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrheal
disease and an important contributor to early-childhood mortality. Waterborne outbreaks …

[HTML][HTML] Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis

D Holthaus, MR Kraft, SM Krug, S Wolf, A Müller… - Gastroenterology, 2022 - Elsevier
Background & Aims The protozoa Giardia duodenalis is a major cause of gastrointestinal
illness worldwide, but underlying pathophysiological mechanisms remain obscure, partly …

Factors associated with dehydrating rotavirus diarrhea in children under five in Bangladesh: An urban-rural comparison

S Yeasmin, SMT Hasan, MJ Chisti, MA Khan… - Plos one, 2022 - journals.plos.org
Introduction Rotavirus is the leading cause of dehydrating diarrhea in young children
worldwide. This study aimed to identify the factors associated with dehydrating rotavirus …

Global projections of temperature-attributable mortality due to enteric infections: a modelling study

PLC Chua, V Huber, CFS Ng, XT Seposo… - The Lancet Planetary …, 2021 - thelancet.com
Background Mortality due to enteric infections is projected to increase because of global
warming; however, the different temperature sensitivities of major enteric pathogens have …

Molecular diversity of Giardia duodenalis in children under 5 years from the Manhiça district, Southern Mozambique enrolled in a matched case-control study on the …

A Messa Jr, PC Köster, M Garrine… - PLoS Neglected …, 2021 - journals.plos.org
Giardia duodenalis is an enteric parasite commonly detected in children. Exposure to this
organism may lead to asymptomatic or symptomatic infection. Additionally, early-life …