Post-traumatic osteoarthritis: a review of pathogenic mechanisms and novel targets for mitigation
Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury and accounts for
12% of all osteoarthritis. These injuries, often of the lower extremity joints, occur due to …
12% of all osteoarthritis. These injuries, often of the lower extremity joints, occur due to …
[HTML][HTML] Inflammatory mechanisms in post-traumatic osteoarthritis: a role for CaMKK2
KC Riggs, U Sankar - Immunometabolism, 2023 - journals.lww.com
Post-traumatic osteoarthritis (PTOA) is a multifactorial disease of the cartilage, synovium,
and subchondral bone resulting from direct joint trauma and altered joint mechanics after …
and subchondral bone resulting from direct joint trauma and altered joint mechanics after …
[HTML][HTML] Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model
C Lin, Z Chen, D Guo, L Zhou, S Lin, C Li, S Li… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Osteopontin (OPN) has been proved to be closely related to the pathogenesis of
osteoarthritis (OA), but the role of OPN in the pathogenesis of OA has not been fully clarified …
osteoarthritis (OA), but the role of OPN in the pathogenesis of OA has not been fully clarified …
Pathological progression of osteoarthritis: a perspective on subchondral bone
X Li, W Chen, D Liu, P Chen, S Wang, F Li, Q Chen… - Frontiers of …, 2024 - Springer
Osteoarthritis (OA) is a degenerative bone disease associated with aging. The rising global
aging population has led to a surge in OA cases, thereby imposing a significant …
aging population has led to a surge in OA cases, thereby imposing a significant …
[HTML][HTML] Molecular mechanisms and potential applications of chondroitin sulphate in managing post-traumatic osteoarthritis
I Golovach, D Rekalov, Y Akimov, H Kostenko… - …, 2023 - ncbi.nlm.nih.gov
Abstract Post-traumatic osteoarthritis (PTOA), a disorder of the synovium, subchondral bone,
and cartilage that affects the entire joint, constitutes approximately 12% of all cases of …
and cartilage that affects the entire joint, constitutes approximately 12% of all cases of …
Tissue catabolism and donor-specific dexamethasone response in a human osteochondral model of post-traumatic osteoarthritis
RM Black, LL Flaman, K Lindblom… - Arthritis Research & …, 2022 - Springer
Background Post-traumatic osteoarthritis (PTOA) does not currently have clinical prognostic
biomarkers or disease-modifying drugs, though promising candidates such as …
biomarkers or disease-modifying drugs, though promising candidates such as …
Jintiange capsules ameliorate osteoarthritis by modulating subchondral bone remodeling and protecting cartilage against degradation
C Zhuang, Z Wang, W Chen, H Wang… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is the most prevalent joint disease worldwide, making it a major cause of
pain and disability. Identified as a chronic and progressive disease, effective treatment at the …
pain and disability. Identified as a chronic and progressive disease, effective treatment at the …
SDF-1α promotes subchondral bone sclerosis and aggravates osteoarthritis by regulating the proliferation and osteogenic differentiation of bone marrow …
Z Meng, L Xin, B Fan - BMC Musculoskeletal Disorders, 2023 - Springer
Background Subchondral bone sclerosis is a major feature of osteoarthritis (OA), and bone
marrow mesenchymal stem cells (BMSCs) are presumed to play an important role in …
marrow mesenchymal stem cells (BMSCs) are presumed to play an important role in …
[HTML][HTML] Increased Sparc release from subchondral osteoblasts promotes articular chondrocyte degeneration under estrogen withdrawal
A Jiang, P Xu, Z Yang, Z Zhao, Q Tan, W Li… - Osteoarthritis and …, 2023 - Elsevier
Objective The incidence of osteoarthritis (OA) in menopausal women is significantly higher
than in same-aged men. Investigating the role of subchondral osteoblasts in estrogen …
than in same-aged men. Investigating the role of subchondral osteoblasts in estrogen …
[HTML][HTML] Dickkopf‑3 and β‑catenin play opposite roles in the Wnt/β‑catenin pathway during the abnormal subchondral bone formation of human knee osteoarthritis
X Liang, Q Jin, X Yang, W Jiang - International …, 2022 - build.spandidos-publications.com
Osteoarthritis (OA) is condition which poses a main concern to the aging population and its
severity is expected to increase with the increasing life expectancy. In the future, several …
severity is expected to increase with the increasing life expectancy. In the future, several …