Rationale Mitragyna speciosa (kratom) may hold promise as both an analgesic and
treatment for opioid use disorder. Mitragynine, its primary alkaloid constituent, is an opioid …

Abstract Ethnopharmacological relevance Kratom (Mitragyna speciosa Korth.) from the
Rubiaceae family is an indigenous tropical medicinal tree of Southeast Asia. Kratom leaves …

Background Kratom (Mitragyna speciosa) is a tropical tree with a long history of traditional
use in parts of Africa and Southeast Asia. Kratom is also known as Thom, Thang, and Biak …

Introduction: Pain relief remains a major public health challenge. The most efficient available
painkillers are opioids targeting the mu opioid receptor (MOR). MORs are expressed in the …

Kratom (Mitragyna speciosa) is a plant indigenous to Southeast Asia. Its leaves and the teas
brewed from them have long been used by people in that region to stave off fatigue and to …

Abstract Background and Purpose Opioid‐induced respiratory depression limits the use of μ‐
opioid receptor agonists in clinical settings and is the main cause of opioid overdose …

Kratom use appears to be increasing across the United States, increasing attention to
deaths in which kratom use was detected. Most such deaths have been ascribed to fentanyl …

There is significant need to find effective, nonaddictive pain medications. κ Opioid receptor
(KOPr) agonists have been studied for decades but have recently received increased …

Kratom products have been historically and anecdotally used in south Asian countries for
centuries to manage pain and opioid withdrawal. The use of kratom products has …

A chiral phosphoric acid‐catalyzed enantioselective aza‐Friedel–Crafts reaction of 5‐
aminopyrazole derivatives with cyclic ketimines attached to a neutral functional group is …