New insights on bioactivities and biosynthesis of flavonoid glycosides

B Yang, H Liu, J Yang, VK Gupta, Y Jiang - Trends in food science & …, 2018 - Elsevier
Flavonoid glycosides are widespread in plants, acting as phytoalexin against biotic stress.
They also have great health benefits to human body. Some of them have been used as …

Microbial production of natural and non-natural flavonoids: pathway engineering, directed evolution and systems/synthetic biology

RP Pandey, P Parajuli, MAG Koffas, JK Sohng - Biotechnology advances, 2016 - Elsevier
In this review, we address recent advances made in pathway engineering, directed
evolution, and systems/synthetic biology approaches employed in the production and …

Bacterial biosynthesis of flavonoids: Overview, current biotechnology applications, challenges, and prospects

CO Okoye, H Jiang, Y Wu, X Li, L Gao… - Journal of Cellular …, 2023 - Wiley Online Library
Flavonoids are secondary metabolites present in plant organs and tissues. These natural
metabolites are the most prevalent and display a wide range of beneficial physiological …

[HTML][HTML] Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products

B He, X Bai, Y Tan, W Xie, Y Feng, GY Yang - Synthetic and Systems …, 2022 - Elsevier
UDP-Glycosyltransferases (UGTs) catalyze the transfer of nucleotide-activated sugars to
specific acceptors, among which the GT1 family enzymes are well-known for their function in …

Engineered production of bioactive polyphenolic O-glycosides

J Ren, CD Barton, J Zhan - Biotechnology Advances, 2023 - Elsevier
Polyphenolic compounds (such as quercetin and resveratrol) possess potential medicinal
values due to their various bioactivities, but poor water solubility hinders their health benefits …

Flavonoids, terpenoids, and polyketide antibiotics: Role of glycosylation and biocatalytic tactics in engineering glycosylation

UM Vasudevan, EY Lee - Biotechnology advances, 2020 - Elsevier
Flavonoids, terpenoids, and polyketides are structurally diverse secondary metabolites used
widely as pharmaceuticals and nutraceuticals. Most of these molecules exist in nature as …

Recent developments in the enzymatic O-glycosylation of flavonoids

B Hofer - Applied microbiology and biotechnology, 2016 - Springer
The glycosylation of bioactive compounds, such as flavonoids, is of particular relevance, as
it modulates many of their pharmacokinetic parameters. This article reviews the literature …

Double promoter expression systems for recombinant protein production by industrial microorganisms

S Öztürk, BG Ergün, P Çalık - Applied Microbiology and Biotechnology, 2017 - Springer
Using double promoter expression systems is a promising approach to increase
heterologous protein production. In this review, current double promoter expression systems …

Microbial Biosynthesis of Chrysazin Derivatives in Recombinant Escherichia coli and Their Biological Activities

PB Poudel, D Dhakal, RT Magar, JK Sohng - Molecules, 2022 - mdpi.com
Anthraquinone and its derivatives show remarkable biological properties such as
anticancer, antibacterial, antifungal, and antiviral activities. Hence, anthraquinones …

3-O-Glucosylation of quercetin enhances inhibitory effects on the adipocyte differentiation and lipogenesis

CW Lee, JY Seo, J Lee, JW Choi, S Cho, JY Bae… - Biomedicine & …, 2017 - Elsevier
Glycosylation of natural flavonoids with various sugar moieties can affect their
physicochemical and pharmacological properties. In this study, the plant flavonoids …