Cancer-associated venous thromboembolism

AA Khorana, N Mackman, A Falanga… - Nature reviews Disease …, 2022 - nature.com
Cancer-associated thrombosis (including venous thromboembolism (VTE) and arterial
events) is highly consequential for patients with cancer and is associated with worsened …

Neutrophil extracellular traps: villains and targets in arterial, venous, and cancer-associated thrombosis

C Thålin, Y Hisada, S Lundström… - … , and vascular biology, 2019 - Am Heart Assoc
Recent studies have demonstrated a role of neutrophils in both venous and arterial
thrombosis. A key prothrombotic feature of neutrophils is their ability to release web-like …

Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway …

A Pottegård, LC Lund, Ø Karlstad, J Dahl, M Andersen… - bmj, 2021 - bmj.com
Objective To assess rates of cardiovascular and haemostatic events in the first 28 days after
vaccination with the Oxford-AstraZeneca vaccine ChAdOx1-S in Denmark and Norway and …

Thrombus structural composition in cardiovascular disease

G Alkarithi, C Duval, Y Shi, FL Macrae… - … , and vascular biology, 2021 - Am Heart Assoc
Thrombosis is a major complication of cardiovascular disease, leading to myocardial
infarction, acute ischemic stroke, or venous thromboembolism. Thrombosis occurs when a …

Inflammation, infection and venous thromboembolism

ME Colling, BE Tourdot, Y Kanthi - Circulation research, 2021 - Am Heart Assoc
The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

Therapeutic strategies for thrombosis: new targets and approaches

N Mackman, W Bergmeier, GA Stouffer… - Nature reviews Drug …, 2020 - nature.com
Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of
thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge …

Fibrinogen and fibrin in hemostasis and thrombosis

S Kattula, JR Byrnes, AS Wolberg - … , thrombosis, and vascular …, 2017 - Am Heart Assoc
Multiple mechanisms mediate thrombin generation and consequently the thrombin
concentration present during fibrin formation. First, the levels of pro-and anticoagulants …

Cryo-shocked platelet coupled with ROS-responsive nanomedicine for targeted treatment of thromboembolic disease

X Quan, X Liang, Y Ding, Y Han, J Li, M Yuan, Y Li… - ACS …, 2023 - ACS Publications
Thrombolysis with tissue plasminogen activator (tPA) provides the most common therapy for
ischemic stroke onset within the past 4.5 h. However, enhanced neutrophil infiltration and …

Platelet GPVI (glycoprotein VI) and thrombotic complications in the venous system

G Perrella, M Nagy, SP Watson… - … , and vascular biology, 2021 - Am Heart Assoc
The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on
megakaryocytes and platelets and is currently recognized as a receptor for not only collagen …

Elaborately engineering a self‐Indicating dual‐drug nanoassembly for site‐specific photothermal‐potentiated thrombus penetration and thrombolysis

Z Zhao, X Zhang, H Zhang, X Shan, M Bai… - Advanced …, 2022 - Wiley Online Library
Thrombotic cardio‐cerebrovascular diseases seriously threaten human health. Currently,
conventional thrombolytic treatments are challenged by the low utilization, inferior thrombus …