The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

An abnormal chromosome number, or aneuploidy, underlies developmental disorders and
is a common feature of cancer, with different cancer types exhibiting distinct patterns of …

Two-thirds of all human conceptions are lost, in most cases before clinical detection. The
lack of detailed understanding of the causes of pregnancy losses constrains focused …

Aneuploidy seriously compromises female fertility and increases incidence of birth defects.
Rates of aneuploidy in human eggs from even young women are significantly higher than …

Advances of aneuploidy research in the maternal germline | Nature Reviews Genetics Skip to
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After fertilization, remodeling of the oocyte and sperm genomes is essential to convert these
highly differentiated and transcriptionally quiescent cells into early cleavage‐stage …

During meiosis, pairing of homologous chromosomes (homologs) ensures the formation of
haploid gametes from diploid precursor cells, a prerequisite for sexual reproduction. Pairing …

Meiosis is the specialized cellular program that underlies gamete formation for sexual
reproduction. It is therefore not only interesting but also a fundamentally important subject for …

After fertilization, remodeling of the oocyte and sperm genome is essential for the successful
initiation of mitotic activity in the fertilized oocyte and subsequent proliferative activity of the …

The centromere is an epigenetic mark that is a loading site for the kinetochore during
meiosis and mitosis. This mark is characterized by the H3 variant CENP-A, known as CID in …