[HTML][HTML] SARS-CoV-2 viral load is associated with increased disease severity and mortality

J Fajnzylber, J Regan, K Coxen, H Corry… - Nature …, 2020 - nature.com
The relationship between SARS-CoV-2 viral load and risk of disease progression remains
largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 …

[HTML][HTML] A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

J Yang, W Wang, Z Chen, S Lu, F Yang, Z Bi, L Bao… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a respiratory
disease called coronavirus disease 2019 (COVID-19), the spread of which has led to a …

[HTML][HTML] Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020

A Singanayagam, M Patel, A Charlett… - …, 2020 - eurosurveillance.org
Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract
peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate …

[HTML][HTML] Aerosol transmission of SARS-CoV-2? Evidence, prevention and control

S Tang, Y Mao, RM Jones, Q Tan, JS Ji, N Li… - Environment …, 2020 - Elsevier
As public health teams respond to the pandemic of coronavirus disease 2019 (COVID-19),
containment and understanding of the modes of severe acute respiratory syndrome …

[PDF][PDF] A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice

SR Leist, KH Dinnon, A Schäfer, VT Longping, K Okuda… - Cell, 2020 - cell.com
The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We
generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures …

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

KS Corbett, MC Nason, B Flach, M Gagne, S O'Connell… - Science, 2021 - science.org
INTRODUCTION Mass vaccination against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) offers the most efficient public health intervention to control the COVID-19 …

[HTML][HTML] COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

RL Chua, S Lukassen, S Trump, BP Hennig… - Nature …, 2020 - nature.com
To investigate the immune response and mechanisms associated with severe coronavirus
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …

[HTML][HTML] Scaling up COVID-19 rapid antigen tests: promises and challenges

RW Peeling, PL Olliaro, DI Boeras… - The Lancet infectious …, 2021 - thelancet.com
WHO recommends a minimum of 80% sensitivity and 97% specificity for antigen-detection
rapid diagnostic tests (Ag-RDTs), which can be used for patients with symptoms consistent …

[PDF][PDF] In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

D Li, RJ Edwards, K Manne, DR Martinez, A Schäfer… - Cell, 2021 - cell.com
Summary SARS-CoV-2-neutralizing antibodies (NAbs) protect against COVID-19. A concern
regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we …

A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples

VL Dao Thi, K Herbst, K Boerner, M Meurer… - Science translational …, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 (severe
acute respiratory syndrome coronavirus 2) coronavirus is a major public health challenge …