Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated
55–60% of those infected developing COVID-19. Since the beginning of the pandemic in …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis causes cerebral dysfunction in the short and long term and induces …

Dysregulated host response to infection, which cause life‐threatening organ dysfunction,
was defined as sepsis. Sepsis can cause acute and long‐term brain dysfunction, namely …

Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis
causing delirium, coma, and long-term cognitive dysfunction. We identified microglia and …

Background Microglial activation-mediated neuroinflammation is one of the essential
pathogenic mechanisms of sepsis-associated encephalopathy (SAE). Mounting evidence …

We examine similar and differential effects of two senolytic treatments, ABT‐263 and
dasatinib+ quercetin (D+ Q), in preserving cognition, markers of peripheral senescence, and …

Sepsis-associated encephalopathy (SAE) is one of the common serious complications in
sepsis, and the pathogenesis of SAE remains unclear. Sirtuin 1 (SIRT1) has been reported …

Background In sepsis, brain dysfunction is known as Sepsis-associated encephalopathy
(SAE), which often results in severe cognitive and neurological sequelae and increases the …

Background Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction,
characterized by cognitive and memory impairments closely linked to hippocampal …

Abstract SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, belongs to a
broad family of coronaviruses that also affect humans. SARS-CoV-2 infection usually leads …