[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

M Fedele, R Piersanti, F Regazzoni, M Salvador… - Computer Methods in …, 2023 - Elsevier
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

Inverse problems in blood flow modeling: A review

D Nolte, C Bertoglio - International journal for numerical …, 2022 - Wiley Online Library
Mathematical and computational modeling of the cardiovascular system is increasingly
providing non‐invasive alternatives to traditional invasive clinical procedures. Moreover, it …

A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

M Bucelli, A Zingaro, PC Africa… - … journal for numerical …, 2023 - Wiley Online Library
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

R Piersanti, PC Africa, M Fedele, C Vergara… - Computer Methods in …, 2021 - Elsevier
Since myocardial fibers drive the electric signal propagation throughout the myocardium,
accurately modeling their arrangement is essential for simulating heart electrophysiology …

[HTML][HTML] Electro-mechanical whole-heart digital twins: a fully coupled multi-physics approach

T Gerach, S Schuler, J Fröhlich, L Lindner… - Mathematics, 2021 - mdpi.com
Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …

Active force generation in cardiac muscle cells: mathematical modeling and numerical simulation of the actin-myosin interaction

F Regazzoni, L Dedè, A Quarteroni - Vietnam Journal of Mathematics, 2021 - Springer
Cardiac in silico numerical simulations are based on mathematical models describing the
physical processes involved in the heart function. In this review paper, we critically survey …

[HTML][HTML] A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation

F Regazzoni, M Salvador, PC Africa, M Fedele… - Journal of …, 2022 - Elsevier
We propose a novel mathematical and numerical model for cardiac electromechanics,
wherein biophysically detailed core models describe the different physical processes …

[HTML][HTML] A machine learning method for real-time numerical simulations of cardiac electromechanics

F Regazzoni, M Salvador, L Dedè… - Computer methods in …, 2022 - Elsevier
We propose a machine learning-based method to build a system of differential equations
that approximates the dynamics of 3D electromechanical models for the human heart …

[HTML][HTML] 3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics

R Piersanti, F Regazzoni, M Salvador, AF Corno… - Computer Methods in …, 2022 - Elsevier
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …

[HTML][HTML] Machine learning of multiscale active force generation models for the efficient simulation of cardiac electromechanics

F Regazzoni, L Dedè, A Quarteroni - Computer Methods in Applied …, 2020 - Elsevier
High fidelity (HF) mathematical models describing the generation of active force in the
cardiac muscle tissue typically feature a large number of state variables to capture the …