Background Epidemic increases in opioid deaths prompted policies limiting access to
prescription opioids in North America. Consequently, the over-the-counter opioids …

The challenge posed by opioid overdose has become a significant concern for health
systems due to the complexities associated with drug prohibition, widespread clinical use …

Aims Prescribed opioids are commonly used in the older community‐dwelling population for
the treatment of chronic pain. Although the harmful effects of opioid abuse and overdose are …

There are few biomarkers to reflect the physiological conditions for substance misuse. In this
study, autonomic nervous and cardiovascular parameters were measured for participants in …

Methods and results We conducted searches in PUBMED and MEDLINE for clinical trials
and reviews done on the efficacy and safety of methadone used for analgesia in chronic …

Objectives: To characterize the associations between SDB, intermittent hypoxemia, and the
QT variability index (QTVI), a measure of ventricular repolarization lability associated with a …

Methadone In Chronic Non-Oncological Pain: From Disassuefaction Of Painkillers Abuse To The
Primary Management Of Opioid Hyperal Page 1 Open Peer Review on Qeios Methadone In …

Dr. Haigney is a board-certified cardiologist and electrophysiologist who attends in the
Cardiology and Cardiogenetics clinics at the Walter Reed National Military Medical Center …