Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial
intima. It is characterized by the dysfunction of lipid homeostasis and signaling pathways …

Alzheimer's disease (AD) is the most common type of dementia characterized by the
deposition of amyloid beta (Aβ) plaques and tau-neurofibrillary tangles in the brain. Visceral …

Overweight, obesity, and type 2 diabetes mellitus pose global health problems that are ever-
increasing. A chronic low-grade inflammatory status and the presence of various pro …

Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is secreted mostly by hepatocytes
and to a lesser extent by the intestine, pancreas, kidney, adipose tissue, and vascular cells …

Inspired by the recent advancements in understanding the binding mode of sulfonylurea-
based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors …

Background & aims Although intermittent energy restriction (IER) seems to be as effective as
continuous energy restriction (CER) for weight loss, there is still a need to determine the …

DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …

Obesity, which is driven by inflammation and oxidative stress, is a risk factor for
cardiovascular disease. Semaglutide, a glucagon-like peptide-1 receptor agonist, is an …

Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) are frequently
associated conditions characterized by low-grade inflammation. Very low-calorie ketogenic …

Diet-induced metabolic diseases, such as obesity, metabolic syndrome, and type 2 diabetes
(T2DM) are the global threatening epidemics that share cardiovascular oxidative stress as …