Simple Summary Tumor stroma is known to significantly influence cancer initiation and
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …

Although many studies have focused on oncology and therapeutics in cancer, cancer
remains one of the leading causes of death worldwide. Due to the unclear molecular …

Androgen deprivation therapy has a central role in the treatment of advanced prostate
cancer, often causing initial tumour remission before increasing independence from signal …

Highlights•Existing models for drug discovery and development against glioblastoma
multiforme (GBM) have limitations.•We review advances in 3D systems that promise more …

Assessment of hypoxia, nutrients, metabolite gradients, and other hallmarks of the tumor
microenvironment within 3D multicellular spheroid and organoid models represents a …

The study of prostate cancer in vitro relies on established cell lines that lack important
physiological characteristics, such as proper polarization and expression of relevant …

Radiation therapy is one of the most effective tools in cancer therapy. However, success
varies individually, necessitating improved understanding of radiobiology. Three …

Three-dimensional (3D) cell culture models can help bridge the gap between in vitro cell
cultures and in vivo responses by more accurately simulating the natural in vivo …

Metastatic prostate cancer (mPCa) is resistant to several chemotherapeutic agents.
Brachydin A (BrA), a glycosylated flavonoid extracted from Fridericia platyphylla, displays a …

Cell culture is important for the rapid screening of anti-cancer drug candidates, attracting
intense interest. Traditional 2D cell culture has been widely utilized in cancer biological …