Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

[HTML][HTML] Stem cell-derived exosome in cardiovascular diseases: macro roles of micro particles

Y Yuan, W Du, J Liu, W Ma, L Zhang, Z Du… - Frontiers in …, 2018 - frontiersin.org
The stem cell-based therapy has emerged as the promising therapeutic strategies for
cardiovascular diseases (CVDs). Recently, increasing evidence suggest stem cell-derived …

N-cadherin overexpression mobilizes the protective effects of mesenchymal stromal cells against ischemic heart injury through a β-catenin–dependent manner

W Yan, C Lin, Y Guo, Y Chen, Y Du, WB Lau… - Circulation …, 2020 - Am Heart Assoc
Rationale: Mesenchymal stromal cell–based therapy is promising against ischemic heart
failure. However, its efficacy is limited due to low cell retention and poor paracrine function …

[HTML][HTML] New approaches for enhancement of the efficacy of mesenchymal stem cell-derived exosomes in cardiovascular diseases

L Ahmed, K Al-Massri - Tissue Engineering and Regenerative Medicine, 2022 - Springer
Cardiovascular diseases (CVDs) remain a major health concern worldwide, where
mesenchymal stem cells (MSCs) therapy gives great promise in their management through …

[HTML][HTML] Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?

CD Correia, A Ferreira, MT Fernandes, BM Silva… - Cells, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO)
as the leading cause of death, contributing to a significant and growing global health and …

Mesenchymal stem cell transplantation for ischemic diseases: mechanisms and challenges

TT Van Nguyen, NB Vu, P Van Pham - Tissue Engineering and …, 2021 - Springer
Ischemic diseases are conditions associated with the restriction or blockage of blood supply
to specific tissues. These conditions can cause moderate to severe complications in …

[HTML][HTML] Mesenchymal stem cells in systemic sclerosis: allogenic or autologous approaches for therapeutic use?

P Rozier, A Maria, R Goulabchand… - Frontiers in …, 2018 - frontiersin.org
Systemic sclerosis (SSc) is a rare autoimmune disease, which is potentially lethal. The
physiopathology of the disease is still incompletely elucidated although the role of …

Elabela gene therapy promotes angiogenesis after myocardial infarction

L Jin, Y Pan, Q Li, J Li, Z Wang - Journal of cellular and …, 2021 - Wiley Online Library
This study was aimed at investigating whether Elabela (ELA) gene therapy can promote
angiogenesis in the treatment of myocardial infarction (MI). The fusion expression plasmid …

MHY2233 Attenuates Replicative Cellular Senescence in Human Endothelial Progenitor Cells via SIRT1 Signaling

S Lamichane, SH Baek, YJ Kim, JH Park… - Oxidative medicine …, 2019 - Wiley Online Library
Cardiovascular diseases (CVDs) are a major cause of death worldwide. Due to the
prevalence of many side effects and incomplete recovery from pharmacotherapies, stem cell …

Systemic and local delivery of mesenchymal stem cells for heart renovation: Challenges and innovations

Z Liu, R Mikrani, HM Zubair, A Taleb, M Naveed… - European journal of …, 2020 - Elsevier
In the beginning stage of heart disease, the blockage of blood flow frequently occurs due to
the persistent damage and even death of myocardium. Cicatricial tissue developed after the …