The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance …

The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …

There are different types of nutritionally mediated oxidative stress sources that trigger
inflammation. Much information indicates that high intakes of macronutrients can promote …

The prevalence of obesity has recently increased dramatically and has contributed to the
increasing prevalence of various pathological conditions, including type 2 diabetes mellitus …

Because current therapeutics for obesity are limited and only offer modest improvements,
novel interventions are needed. Preventing obesity with time-restricted feeding (TRF; 8–9 hr …

One of the most promising areas in the therapeutics for metabolic diseases centers around
activation of the pathways of energy expenditure. Brown adipose tissue is a particularly …

Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which
precedes the development of type 2 diabetes mellitus and is thus the driving force behind …

Metabolism and immunity are inextricably linked both to each other and to organism-wide
function, allowing mammals to adapt to changes in their internal and external environments …

Emerging evidence suggests that inflammation provides a link between obesity and insulin
resistance. The noncanonical IκB kinases IKK-ɛ and TANK-binding kinase 1 (TBK1) are …