Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for
regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti …

Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Obesity increases the risk for metabolic, cardiovascular, chronic inflammatory, and several
malignant diseases and, therefore, may contribute to shortened lifespan. Adipokines are …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Adiponectin is one of the most important adipocytokines secreted by adipocytes and is
called a “guardian angel adipocytokine” owing to its unique biological functions. Adiponectin …

This year marks the 20th anniversary of the discovery of leptin, which has tremendously
stimulated translational obesity research. The discovery of leptin has led to realizations that …

Abstract Purpose of Review Obesity and obesity-related diseases, largely resulting from
urbanization and behavioral changes, are now of global importance. Energy restriction …

A hallmark of type 2 diabetes mellitus (T2DM) is the development of pancreatic β cell failure,
which results in insulinopenia and hyperglycemia. We show that the adipokine adipsin has a …

Obesity is associated with an array of health problems in adult and pediatric populations.
Understanding the pathogenesis of obesity and its metabolic sequelae has advanced …