The accumulation of CD28− T cells, particularly within the CD8 subset, is one of the most
prominent changes during T-cell homeostasis and function associated with aging in …

On antigen encounter, naïve CD8+ and CD4+ T cells differentiate into a large number of
effector cells that migrate to inflamed tissues to fight infections or tumors. Following …

A balanced host‐parasite interaction during Trypanosoma cruzi infection allows for the
establishment of a chronic infection that can last for many years. T cells are a major element …

Deterioration of lung functions and degradation of elastin fibers with age are accelerated
during chronic obstructive pulmonary disease (COPD). Excessive genesis of soluble elastin …

Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the
autoimmune destruction of the small intrahepatic bile ducts. The disease has an …

Обзор посвящен иммунной системе слизистой оболочки кишечника, которая
представлена лимфоидной тканью, ассоциированной со слизистой оболочкой-MALT …

We describe the first clinical application of T‐cell‐recruiting bispecific antibodies directly into
the tumor without the need to preactivate the effector cells. In a Phase I clinical trial, 10 …

BACKGROUND: The role of CD8+ T cells in the immune response to airway challenge with
an allergen is poorly understood. OBJECTIVE: The aim of this study was to test the …

In this paper the contribution of different accessory molecules to the adhesion of resting,
naive and memory CD4+ T cells was examined utilizing a panel of CHO cell transfectants as …

In advance of using bispecific antibodies for the treatment of B cell lymphoma in humans, we
analysed CD3× CD19 bispecific antibodies for their capacity to induce T cell activiation in …