[HTML][HTML] Integrated transcriptome and metabolome analyses reveal the adaptation of Antarctic moss Pohlia nutans to drought stress
S Fang, T Li, P Zhang, C Liu, B Cong… - Frontiers in Plant Science, 2022 - frontiersin.org
Most regions of the Antarctic continent are experiencing increased dryness due to global
climate change. Mosses and lichens are the dominant vegetation of the ice-free areas of …
climate change. Mosses and lichens are the dominant vegetation of the ice-free areas of …
Characterization of enzymes involved in nintedanib metabolism in humans
S Nakashima, R Sato, T Fukami, T Kudo… - Drug Metabolism and …, 2023 - ASPET
Nintedanib, which is used to treat idiopathic pulmonary fibrosis and non–small cell lung
cancer, is metabolized to a pharmacologically inactive carboxylate derivative, BIBF1202, via …
cancer, is metabolized to a pharmacologically inactive carboxylate derivative, BIBF1202, via …
Regulation of human hydrolases and its implications in pharmacokinetics and pharmacodynamics
SM Jung, HJ Zhu - Drug Metabolism and Disposition, 2024 - ASPET
Hydrolases represent an essential class of enzymes indispensable for the metabolism of
various clinically essential medications. Individuals exhibit marked differences in the …
various clinically essential medications. Individuals exhibit marked differences in the …
Evaluation of the inhibitory effects of antigout drugs on human carboxylesterases in vitro
J Liang, X Yi, J Gong, Z Du - Toxicology in Vitro, 2024 - Elsevier
Gout is an immune-metabolic disease that frequently coexists with multiple comorbidities
such as chronic kidney disease, cardiovascular disease and metabolic syndrome, therefore …
such as chronic kidney disease, cardiovascular disease and metabolic syndrome, therefore …
[PDF][PDF] 表没食子儿茶素没食子酸酯药动学及其药物相互作用研究进展
陈思文， 吕月， 张凯娜 - 中国药理学与毒理学杂志, 2023 - cjpt.magtechjournal.com
表没食子儿茶素没食子酸酯(EGCG) 是茶多酚中主要的生物活性物质, 有良好的临床应用前景.
但是EGCG 口服生物利用度差, 大部分进入肠道, 经尿便排泄; 静脉给药后主要分布在肝 …
但是EGCG 口服生物利用度差, 大部分进入肠道, 经尿便排泄; 静脉给药后主要分布在肝 …
Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans …
C Makino, A Watanabe, M Kato, H Shiozawa… - Drug Metabolism and …, 2022 - Elsevier
Our previous study in rats demonstrated that the metabolic pathways of DS-8500a, a novel
GPR119 agonist, include cleavage pathways: reductive cleavage of the oxadiazole ring in …
GPR119 agonist, include cleavage pathways: reductive cleavage of the oxadiazole ring in …
Cationic Ester Prodrugs of Curcumin with N,N-dimethyl Amino Acid Promoieties Improved Poor Water Solubility and Intestinal Absorption
M Hirano-Kusuda, S Setoguchi, M Koga, S Goto… - Pharmaceutical …, 2023 - Springer
Abstract Purpose Although curcumin (Cur) has powerful pharmacological effects, its use in
medicine has not been established yet. The oral bioavailability (BA) of Cur is limited …
medicine has not been established yet. The oral bioavailability (BA) of Cur is limited …